Myocardial Oxygenation Imaging: New Methods for Ischemia Detection

被引:0
作者
Zheng J. [1 ,2 ]
机构
[1] Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO
[2] Cardiovascular Imaging Lab, St. Louis, MO, 63110, 4525 Scott Avenue
关键词
BOLD; CMR; Myocardium; Oxygenation;
D O I
10.1007/s12410-010-9063-3
中图分类号
学科分类号
摘要
Myocardial ischemia is associated with many cardiovascular diseases, including coronary artery disease, congestive heart failure, hypertensive left ventricular hypertrophy, and diabetic cardiomyopathy, etc. The ischemia is caused by the imbalance of myocardial oxygen supply and demand. Positron emission tomography (PET) is the only noninvasive imaging technique to directly measure myocardial oxygenation. However, its low spatial resolution, limited availability, and ionizing radiation discourage the widespread use of PET to detect myocardial ischemia in clinical practice. The cardiac BOLD (blood-oxygen-level dependence) effect allows the measurement of myocardial oxygenation through T2 or T2* change using cardiac magnetic resonance (CMR) imaging techniques. Many efforts were made to improve the sensitivity of detecting this change and image quality for clinical evaluations. With relatively high spatial resolution, oxygenation in the subendocardium, a common location for myocardial ischemia, for the first time could be directly assessed by CMR oxygenation imaging. This method, combined with other CMR functional and anatomic imaging, will offer a one-stop shop for the detection of myocardial ischemia, even in the absence of angiographically significant coronary artery stenosis. © 2010 Springer Science+Business Media, LLC.
引用
收藏
页码:159 / 164
页数:5
相关论文
共 50 条
[41]   Effects of caffeine on the detection of ischemia in patients undergoing adenosine stress cardiovascular magnetic resonance imaging [J].
Simon Greulich ;
Philipp Kaesemann ;
Andreas Seitz ;
Stefan Birkmeier ;
Eed Abu-Zaid ;
Francesco Vecchio ;
Udo Sechtem ;
Heiko Mahrholdt .
Journal of Cardiovascular Magnetic Resonance, 19
[42]   Effects of caffeine on the detection of ischemia in patients undergoing adenosine stress cardiovascular magnetic resonance imaging [J].
Greulich, Simon ;
Kaesemann, Philipp ;
Seitz, Andreas ;
Birkmeier, Stefan ;
Abu-Zaid, Eed ;
Vecchio, Francesco ;
Sechtem, Udo ;
Mahrholdt, Heiko .
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2017, 19
[43]   Development of a new index of oxygenation [J].
Kathirgamanathan, A. ;
Hardman, J. G. .
BRITISH JOURNAL OF ANAESTHESIA, 2008, 100 (04) :585P-586P
[44]   Detection of Myocardial Fibrosis in Systemic Sclerosis by Contrast-Enhanced Magnetic Resonance Imaging [J].
Nassenstein, K. ;
Breuckmann, F. ;
Huger, M. ;
Ladd, S. C. ;
Schlosser, T. ;
Kreuter, A. ;
Barkhausen, J. .
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN, 2008, 180 (12) :1054-1060
[45]   DETECTION OF MYOCARDIAL-ISCHEMIA BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY DURING HANDGRIP EXERCISE [J].
YABE, T ;
MITSUNAMI, K ;
OKADA, M ;
MORIKAWA, S ;
INUBUSHI, T ;
KINOSHITA, M .
CIRCULATION, 1994, 89 (04) :1709-1716
[46]   Dysregulated Adenosine Methylation of RNA in Myocardial Ischemia [J].
Mathiyalagan, Prabhu ;
Martins, Adriano ;
Liang, Yaxuan ;
Chen, Jiqiu ;
Kohlbrenner, Erik ;
Lebeche, Djamel ;
Trivieri, Maria G. ;
Ishikawa, Kiyotake ;
Fish, Kenneth ;
Hajjar, Roger J. ;
Sahoo, Susmita .
CIRCULATION, 2016, 134
[47]   Peroxynitrite in myocardial ischemia-reperfusion injury [J].
Lalu M.M. ;
Wang W. ;
Schulz R. .
Heart Failure Reviews, 2002, 7 (4) :359-369
[48]   Myocardial tissue oxygenation estimated with calibrated diffuse reflectance spectroscopy during coronary artery bypass grafting [J].
Haggblad, Erik ;
Lindbergh, Tobias ;
Karlsson, M. G. Daniel ;
Casimir-Ahn, Henrik ;
Salerud, E. Goran ;
Stromberg, Tomas .
JOURNAL OF BIOMEDICAL OPTICS, 2008, 13 (05)
[49]   Dysregulated Adenosine Methylation of RNA in Myocardial Ischemia [J].
Mathiyalagan, Prabhu ;
Martins, Adriano ;
Liang, Yaxuan ;
Chen, Jiqiu ;
Kohlbrenner, Erik ;
Lebeche, Djamel ;
Trivieri, Maria G. ;
Ishikawa, Kiyotake ;
Fish, Kenneth ;
Hajjar, Roger J. ;
Sahoo, Susmita .
CIRCULATION, 2016, 134
[50]   Dynamic handgrip exercise for the detection of myocardial ischemia using fast Strain-ENCoded cardiovascular magnetic resonance [J].
Ochs, Andreas ;
Nippes, Michael ;
Salatzki, Janek ;
Weberling, Lukas D. ;
Osman, Nael ;
Riffel, Johannes ;
Katus, Hugo A. ;
Friedrich, Matthias G. ;
Frey, Norbert ;
Ochs, Marco M. ;
Andre, Florian .
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2025, 27 (01)