CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer’s disease risk in an APOE-dependent manner

被引:0
|
作者
Elizabeth A. Murphy
John Cooper Roddey
Linda K. McEvoy
Dominic Holland
D. J. Hagler
Anders M. Dale
James B. Brewer
机构
[1] University of California,Department of Neurosciences
[2] University of California,Department of Radiology
[3] University of California,Multimodal Imaging Laboratory
[4] Human Memory Laboratory,undefined
来源
Brain Imaging and Behavior | 2012年 / 6卷
关键词
Imaging genetics; Quantitative neuroimaging; CETP; Alzheimer’s disease; Dementia; APOE;
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学科分类号
摘要
Two alleles in cholesteryl ester transfer protein (CETP) gene polymorphisms have been disputably linked to enhanced cognition and decreased risk of Alzheimer’s disease (AD): the V and A alleles of I405V and C-629A. This study investigates whether these polymorphisms affect brain structure in 188 elderly controls and 318 AD or mild cognitive impairment (MCI) subjects from the Alzheimer’s Disease Neuroimaging Initiative cohort. Nominally signficant associations were dependent on APOE ε4 carrier status. In APOE ε4 carriers, the V and A alleles, both of which decrease CETP and increase HDL, associated with greater baseline cortical thickness and less 12-month atrophy in the medial temporal lobe. Conversely, in APOE ε4 non-carriers, the I allele, which increases CETP and decreases HDL, associated with greater baseline thickness, less atrophy and lower risk of dementia. These results suggest CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner.
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页码:16 / 26
页数:10
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