The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

被引：0
作者：
Jordi Barretina
Giordano Caponigro
Nicolas Stransky
Kavitha Venkatesan
Adam A. Margolin
Sungjoon Kim
Christopher J. Wilson
Joseph Lehár
Gregory V. Kryukov
Dmitriy Sonkin
Anupama Reddy
Manway Liu
Lauren Murray
Michael F. Berger
John E. Monahan
Paula Morais
Jodi Meltzer
Adam Korejwa
Judit Jané-Valbuena
Felipa A. Mapa
Joseph Thibault
Eva Bric-Furlong
Pichai Raman
Aaron Shipway
Ingo H. Engels
Jill Cheng
Guoying K. Yu
Jianjun Yu
Peter Aspesi
Melanie de Silva
Kalpana Jagtap
Michael D. Jones
Li Wang
Charles Hatton
Emanuele Palescandolo
Supriya Gupta
Scott Mahan
Carrie Sougnez
Robert C. Onofrio
Ted Liefeld
Laura MacConaill
Wendy Winckler
Michael Reich
Nanxin Li
Jill P. Mesirov
Stacey B. Gabriel
Gad Getz
Kristin Ardlie
Vivien Chan
Vic E. Myer
机构：
[1] The Broad Institute of Harvard and MIT,Department of Medical Oncology
[2] Dana-Farber Cancer Institute,Department of Pediatric Oncology
[3] Harvard Medical School,undefined
[4] Center for Cancer Genome Discovery,undefined
[5] Dana-Farber Cancer Institute,undefined
[6] Harvard Medical School,undefined
[7] Novartis Institutes for Biomedical Research,undefined
[8] Genomics Institute of the Novartis Research Foundation,undefined
[9] Novartis Institutes for Biomedical Research,undefined
[10] Dana-Farber Cancer Institute,undefined
[11] Howard Hughes Medical Institute,undefined
[12] Present addresses: Novartis Institutes for Biomedical Research,undefined
[13] Cambridge,undefined
[14] Massachusetts 02139,undefined
[15] USA (J.B.); Sage Bionetworks,undefined
[16] 1100 Fairview Ave. N.,undefined
[17] Seattle,undefined
[18] Washington 98109,undefined
[19] USA (A.A.M.); Department of Pathology,undefined
[20] Memorial Sloan-Kettering Cancer Center,undefined
[21] New York,undefined
[22] New York 10065,undefined
[23] USA (M.F.B.).,undefined
来源：
Nature | 2012年 / 483卷
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摘要：
The Cancer Cell Line Encyclopedia presents the first results from a large-scale screen of some 947 cancer cell lines with 24 anticancer drugs, with the aim of identifying specific genomic alterations and gene expression profiles associated with selective sensitivity or resistance to potential therapeutic agents.
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页码：603 / 607
页数：4
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