Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways

被引：0
作者：
Li Qiang
Jiang Yuan
Jiang Shouyin
Li Yulin
Jiang Libing
Wang Jian-an
机构：
[1] Second Affiliated Hospital of Zhejiang University School of Medicine,Emergency Department
[2] Children’s Hospital,Department of Pulmonology
[3] Zhejiang University School of Medicine,undefined
来源：
Inflammation | 2016年 / 39卷
关键词：
sesamin; LPS; acute lung injury; NF-κB; TLR4;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent studies suggested that TLR4 signaling pathways played an important role in the development of LPS-induced acute lung injury (ALI). Sesamin, a sesame lignan exacted from sesame seeds, has been shown to exhibit significant anti-inflammatory activity. The purpose of this study was to investigate the anti-inflammatory effects of sesamin on LPS-induced ALI in mice. Mice ALI model was induced by intratracheal instillation of LPS. Sesamin was given 1 h after LPS challenge. Our results showed that sesamin inhibited LPS-induced lung pathological change, edema, and myeloperoxidase (MPO) activity. Sesamin suppressed LPS-induced inflammatory cytokines TNF-α, IL-6, and IL-1β production. Furthermore, sesamin inhibited LPS-induced TLR4 expression and NF-κB activation. In conclusion, the results of this study indicated that sesamin protected against LPS-induced ALI by inhibition of TLR4 signaling pathways.
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页码：467 / 472
页数：5
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