Determination of methylparaben, propylparaben, triamcinolone acetonide and its degradation product in a topical cream by RP-HPLC

被引：0
作者：
L. Matysová
R. Hájková
J. Šícha
P. Solich
机构：
[1] Charles University,Department of Analytical Chemistry, Faculty of Pharmacy
[2] The Research Centre LN00B125,Faculty of Pharmacy
[3] Herbacos-Bofarma Ltd.,Bochemie Group
来源：
Analytical and Bioanalytical Chemistry | 2003年 / 376卷
关键词：
HPLC; Pharmaceuticals; Degradation product; Methylparaben; Propylparaben; Triamcinolone acetonide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel reversed-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for the determination of active component triamcinolone acetonide, its degradation product triamcinolone (occurring in formulation after long-term stability tests) and two preservatives presented in the cream—methylparaben and propylparaben, using hydrocortisone as an internal standard.
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页码：440 / 443
页数：3
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