Effect of melatonin on cyclic nucleotide content and intensity of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypoxia

被引：0
|
作者：
Zamorskii I.I. [1 ]
Pishak V.P. [1 ]
机构：
[1] Bukovinskaya State Medical Academy, Chernovtsy
来源：
Bulletin of Experimental Biology and Medicine | 2000年 / 130卷 / 8期
关键词：
Acute hypoxia; Cyclic nucleotides; Forebrain; Heme-oxygenase; Melatonin;
D O I：
10.1007/BF02766086
中图分类号：
学科分类号：
摘要：
Single intraperitoneal injection of melatonin in a dose of 1 mg/kg prevented accumulation of cGMP and intensification of lipid peroxidation in the hippocampus and habenula of rats exposed to acute hypobaric hypoxia (12,000 m). Changes in habenular content of cGMP suggest that melatonin prevents hypoxia-induced activation of heme-oxygenase.
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页码：756 / 758
页数：2
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