Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene

Looareesuwan S(1999)Efficacy and safety of atovaquone/proguanil compared with mefloquine for treatment of acute Am J Trop Med Hyg 60 526-532

Wilairatana P(1999) malaria in Thailand Mol Microbiol 33 704-711

Chalermarut K(2000)Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites Drug Resist Updat 3 283-287

Rattanapong Y(2005)Atovaquone resistance in malaria parasites J Biol Chem 280 17142-17148

Canfield CJ(2003)Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in J Biol Chem 278 31312-31318

Hutchinson DB(2000)Molecular basis for atovaquone binding to the cytochrome bc1 complex Antimicrob Agents Chemother 44 2100-2108

Srivastava IK(2007)Mutations in Nature 446 88-91

Morrisey JM(1997) cytochrome b that are associated with atovaquone resistance are located at a putativedrug-binding site J Biol Chem 272 3961-3966

Darrouzet E(1993)Specific role of mitochondrial electron transport in blood-stage Mol Biochem Parasitol 58 33-42

Daldal F(1999)Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malaria parasite Antimicrob Agents Chemother 43 1334-1339

Looareesuwan S(1999)Efficacy and safety of atovaquone/proguanil compared with mefloquine for treatment of acute Am J Trop Med Hyg 60 526-532

Wilairatana P(1999) malaria in Thailand Mol Microbiol 33 704-711

Chalermarut K(2000)Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites Drug Resist Updat 3 283-287

Rattanapong Y(2005)Atovaquone resistance in malaria parasites J Biol Chem 280 17142-17148

Canfield CJ(2003)Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in J Biol Chem 278 31312-31318

Hutchinson DB(2000)Molecular basis for atovaquone binding to the cytochrome bc1 complex Antimicrob Agents Chemother 44 2100-2108

Srivastava IK(2007)Mutations in Nature 446 88-91

Morrisey JM(1997) cytochrome b that are associated with atovaquone resistance are located at a putativedrug-binding site J Biol Chem 272 3961-3966

Darrouzet E(1993)Specific role of mitochondrial electron transport in blood-stage Mol Biochem Parasitol 58 33-42

Daldal F(1999)Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malaria parasite Antimicrob Agents Chemother 43 1334-1339