The role of anti-CGRP antibodies in the pathophysiology of primary headaches

被引：0
作者：
Piero Barbanti
Cinzia Aurilia
Luisa Fofi
Gabriella Egeo
Patrizia Ferroni
机构：
[1] IRCCS San Raffaele Pisana,Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences
[2] San Raffaele Roma Open University,Department of Human Sciences and Quality of Life Promotion
来源：
Neurological Sciences | 2017年 / 38卷
关键词：
CGRP; Monoclonal CGRP antibodies; Migraine; Headache; Treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Calcitonin gene-related peptide (CGRP), a potent vasodilator and pain-signaling neuropeptide, is a validated therapeutic target for migraine and cluster headache. Four anti-CGRP monoclonal antibodies (mAbs) have been developed, representing the first specific, mechanism-based, migraine prophylactic treatment. CGRP mAbs demonstrated good efficacy coupled to excellent tolerability and safety in 5 phase II clinical trials. Notably, CGRP mAbs induced complete migraine remission in a patients’ subset. To date, more than 20 phase III trials using CGRP mAbs for of episodic and chronic migraine and cluster headache prevention are ongoing. Future investigations will shed light on migraine endophenotypes predictive of good CGRP mAbs responsiveness and provide answers on their long-term cardiovascular safety.
引用
收藏
页码：31 / 35
页数：4
相关论文
共 100 条
  • [1] Edvinsson L(2015)The journey to establish CGRP as a migraine target: a retrospective view Headache 55 1249-1255
  • [2] Edvinsson L(2015)CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment Br J Clin Pharmacol 80 193-199
  • [3] Schuster NM(2016)New strategies for the treatment and prevention of primary headache disorders Nat Rev Neurol 12 635-650
  • [4] Rapoport AM(2014)Calcitonin gene-related peptide: physiology and pathophysiology Physiol Rev 94 1099-1142
  • [5] Russell FA(1997)Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors Neurosci Biobehav Rev 21 649-678
  • [6] King R(2014)Targeting TRP channels for novel migraine therapeutics ACS Chem Neurosci 5 1085-1096
  • [7] Smillie SJ(2014)TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling Cell 157 1023-1036
  • [8] van Rossum D(1985)Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation of release of an endothelium derived relaxing factor in the cat Neurosci Lett 58 213-217
  • [9] Hanisch UK(2002)Role of calcitonin gene-related peptide and its antagonist on the evoked discharge frequency of wide dynamic range neurons in the dorsal horn of the spinal cord in rats Regul Pept 103 23-27
  • [10] Quirion R(2003)Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells Br J Pharmacol 139 1061-1075
12345678910