Metabotropic Glutamate Receptors Stimulate Phospholipase D via Different Pathways in the Adult and Neonate Rat Hippocampus

被引：0
作者：
Sabina Attucci
Serenella Albani-Torregrossa
Flavio Moroni
Domenico E. Pellegrini-Giampietro
机构：
[1] Universitè di Firenze,Dipartimento di Farmacologia Preclinica e Clinica
来源：
Neurochemical Research | 2001年 / 26卷
关键词：
Metabotropic glutamate receptors; phospholipase D; ontogeny; PCCG-13; rat hippocampus;
D O I：
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中图分类号：
学科分类号：
摘要：
In order to characterize the ontogenetic profile of metabotropic glutamate (mGlu) receptors coupled to phospholipase D (PLD) we examined the effects of selected mGlu agents on PLD activity in immature and adult rat hippocampus. The group I mGlu receptor agonist 3,5-dihydroxyphenylglycine stimulated PLD in immature tissue, but reduced the PLD response evoked by the nonselective mGlu receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate [(1S,3R)-ACPD] in adult hippocampus. (2R,1′S,2′R,3′S)-2-(2′-Carboxy-3′-phenylcyclopropyl)glycine (PCCG-13), a recently characterized selective antagonist of PLD-coupled mGlu receptors, displayed a much greater activity in reducing the PLD response to (1S,3R)-ACPD in adult than in neonate hippocampus. Our results lend support to the hypothesis that glutamatergic activation of PLD in the rat hippocampus is developmentally regulated.
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页码：1151 / 1155
页数：4
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