A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

被引：0

作者：

Evangelos Andreakos

Laurent Abel

Donald C. Vinh

Elżbieta Kaja

Beth A. Drolet

Qian Zhang

Cliona O’Farrelly

Giuseppe Novelli

Carlos Rodríguez-Gallego

Filomeen Haerynck

Carolina Prando

Aurora Pujol

Helen C. Su

Jean-Laurent Casanova

András N. Spaan

机构：

[1] Biomedical Research Foundation of the Academy of Athens,Laboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research

[2] Rockefeller Branch,St. Giles Laboratory of Human Genetics of Infectious Diseases

[3] The Rockefeller University,Laboratory of Human Genetics of Infectious Diseases

[4] Necker Branch,Department of Medicine, Division of Infectious Diseases

[5] INSERM U1163,Infectious Disease Susceptibility Program, Research Institute

[6] Necker Hospital for Sick Children,Department of Dermatology

[7] University of Paris,Department of Biomedicine and Prevention

[8] Imagine Institute,Department of Immunology

[9] McGill University Health Centre,Department of Clinical Sciences

[10] Montréal,Department of Pediatric Immunology and Pulmonology, Centre for Primary Immunodeficiency Ghent (CPIG), PID Research Laboratory, Jeffrey Modell Diagnosis and Research Centre

[11] McGill University Health Centre,Department of Medical Microbiology

[12] Montréal,Department of Pediatrics

[13] MNM Diagnostics Inc.,SciLifeLab, Department of Women’s and Children’s Health

[14] School of Medicine and Public Health,Department of Pediatrics and Children’s Healthcare of Atlanta

[15] University of Wisconsin,Murdoch Children’s Research Institute and Department of Paediatrics

[16] Comparative Immunology Group,Department of Immunology

[17] School of Biochemistry and Immunology,Precision Medicine Unit

[18] Trinity Biomedical Sciences Institute,Research Unit

[19] Trinity College Dublin,CIBER de Enfermedades Respiratorias

[20] University of Rome Tor Vergata,Genomics Division

[21] Hospital Universitario de Gran Canaria Dr. Negrín,Department of Paediatrics & Adolescent Medicine

[22] Canarian Health System,Department of Pediatrics, Jeffrey Modell Diagnostic and Research Network Center

[23] Las Palmas de Gran Canaria,Laboratory for Inborn Errors of Immunity, Department of Immunology, Microbiology and Transplantation

[24] University Fernando Pessoa Canarias,Department of Infectious Diseases

[25] Las Palmas de Gran Canaria,Department of Biomedicine

[26] Ghent University Hospital,Department of Pediatrics

[27] Faculdades Pequeno Príncipe,Department of Pediatrics

[28] Instituto de Pesquisa Pelé Pequeno Príncipe,Department of Molecular Biology and Genetics

[29] Neurometabolic Diseases Laboratory,Department of Biosciences and Nutrition

[30] Bellvitge Biomedical Research Institute (IDIBELL),Laboratory of Immunogenetics of Human Diseases

[31] L’Hospitalet de Llobregat,Department of Immunology

[32] Catalan Institution of Research and Advanced Studies (ICREA),Department of Immunology

[33] Center for Biomedical Research on Rare Diseases U759 (CIBERER),Central European Institute of Technology & Department of Biology

[34] ISCIII,Department of Internal Medicine II

[35] Intramural Research Program,Centre for Precision Therapeutics, Genetic and Genomic Medicine Centre

[36] National Institute of Allergy and Infectious Diseases,Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Center

[37] National Institutes of Health,Molecular Biophysics Division

[38] Howard Hughes Medical Institute,undefined

[39] University Medical Center Utrecht,undefined

[40] British Columbia Children’s Hospital,undefined

[41] The University of British Columbia,undefined

[42] Helix,undefined

[43] Shupyk National Healthcare University of Ukraine,undefined

[44] Karolinska Institutet,undefined

[45] Emory University,undefined

[46] University of Melbourne,undefined

[47] Institute of Biomedical Sciences,undefined

[48] University of São Paulo,undefined

[49] De Duve Instute and Cliniques Universitaires Saint Luc,undefined

[50] Université catholique de Louvain,undefined

来源：

Nature Immunology | 2022年 / 23卷

关键词：

D O I：

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学科分类号：

摘要：

SARS-CoV-2 infections display tremendous interindividual variability, ranging from asymptomatic infections to life-threatening disease. Inborn errors of, and autoantibodies directed against, type I interferons (IFNs) account for about 20% of critical COVID-19 cases among SARS-CoV-2-infected individuals. By contrast, the genetic and immunological determinants of resistance to infection per se remain unknown. Following the discovery that autosomal recessive deficiency in the DARC chemokine receptor confers resistance to Plasmodium vivax, autosomal recessive deficiencies of chemokine receptor 5 (CCR5) and the enzyme FUT2 were shown to underlie resistance to HIV-1 and noroviruses, respectively. Along the same lines, we propose a strategy for identifying, recruiting, and genetically analyzing individuals who are naturally resistant to SARS-CoV-2 infection.

引用

页码：159 / 164

页数：5

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