Serum cytokine levels in human ascariasis and toxocariasis

被引:0
作者
Nancy Malla
Bashir Ahmad Fomda
Manzoor Ahmad Thokar
机构
[1] Postgraduate Institute of Medical Education & Research,Department of Parasitology
[2] Sher-I-Kashmir Institute of Medical Sciences,Department of Microbiology
来源
Parasitology Research | 2006年 / 98卷
关键词
Ascaris Lumbricoides; Ascariasis; Helminthic Infection; Toxocariasis; Altered Immune Response;
D O I
暂无
中图分类号
学科分类号
摘要
Cytokine-mediated regulation of chronic intestinal helminth infections is well documented. The present study reports the serum cytokine responses in 38 ascariasis (stool samples positive for Ascaris lumbricoides ova) and toxocariasis (seropositive) patients, 8 ascariasis-positive and toxocariasis-seronegative patients, 22 endemic, normal, healthy subjects residing in areas hyperendemic for ascariasis and 16 normal healthy subjects residing in a low-endemic area in India. The results indicated T-helper type-2-type cytokine responses in ascariasis and toxocariasis (seropositive) and ascariasis-positive and toxocariasis-seronegative patients. The important observation was that both patients and healthy individuals in ascariasis-hyperendemic areas had significantly higher interleukin-5 (IL-5) responses than non-endemic control subjects. The altered immune responses of patients in areas hyperendemic of ascariasis may have further implications. Earlier reports suggest that the geohelminth parasites in endemic areas may modulate the immune response to oral vaccines. A critical role for IL-5 in the immune response against challenge infection consistent with the association of type-2 cytokines with vaccine-mediated protection has been reported. Furthermore, co-infection by pathogens that elicit opposing immune responses, particularly helminths vs HIV and tuberculosis, could influence the infection dynamics, progression and immunoprophylaxis of the diseases they cause. Further studies are warranted to ascertain these findings.
引用
收藏
页码:345 / 348
页数:3
相关论文
共 81 条
[11]  
Bansal D(1996)Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite Gastroenterol Clin North Am 25 553-577
[12]  
Sehgal R(2004)Early cytokine responses during intestinal parasitic infections J Infect Dis 190 427-429
[13]  
Chawla Y(1998)Ascariasis Clin Exp Immunol 114 403-407
[14]  
Malla N(2000)Resistance to helminth infection: the case for Interleukin-5-dependent mechanisms Parasitol Today 16 95-101
[15]  
Mahajan RC(1993)Dynamics of serum cytokines in patients with visceral leishmaniasis and HIV-1 co-infection Proc Natl Acad Sci USA 90 3730-3734
[16]  
Cooper PJ(2004)Do eosinophils have a role in the killing of helminth parasites? J Infect Dis 190 430-438
[17]  
Chico M(2003)Interleukin 13 induces interleukin 4 independent IgG Parasite Immunol 25 361-368
[18]  
Sandoval C(1999) and IgE synthesis and CD23 expression by human B cells Clin Exp Immunol 115 503-507
[19]  
Cooper PJ(2003)Immune responses in human necatoriasis: association between interleukin-5 responses and resistance to reinfection Parasite Immunol 25 393-400
[20]  
Chico M(1995)Influence of maternal infection on offspring immune response in murine larval toxocariasis J Helminthol 69 271-278