In vitro activity of daptomycin in combination with low-dose colistin against a diverse collection of Gram-negative bacterial pathogens

被引：0
作者：
L. Phee
M. Hornsey
D. W. Wareham
机构：
[1] Queen Mary University London,Antimicrobial Research Group, Centre for Immunology and Infectious Disease, Blizard Institute, Barts and the London School of Medicine and Dentistry
[2] Barts Health NHS Trust,Division of Infection
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2013年 / 32卷
关键词：
Colistin; Daptomycin; Tigecycline; Acinetobacter Baumannii; Moraxella Catarrhalis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The activity of colistin in combination with daptomycin was assessed using 30 Gram-negative type strains and multidrug-resistant isolates with defined mechanisms of resistance. Daptomycin minimum inhibitory concentrations (MICs) were determined with and without sub-inhibitory concentrations of colistin. The activity of daptomycin was not affected with respect to Escherichia coli, Klebsiella pneumoniae or Pseudomonas aeruginosa. For colistin-susceptible Acinetobacter baumannii, sensitisation factors ranged from 8 to 128 (median 32), with the daptomycin MIC being reduced to the Clinical and Laboratory Standards Institute (CLSI) enterococci susceptibility breakpoint of 4 μg/ml for the ATCC 19606 type strain. A combination of daptomycin and colistin may be useful for the treatment of A. baumannii but not infections due to other Gram-negative species.
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页码：1291 / 1294
页数：3
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