Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing

被引：0
作者：
Tianxu Fang
Xiaona Cao
Mysha Ibnat
Guojun Chen
机构：
[1] McGill University,Department of Biomedical Engineering
[2] McGill University,Rosalind & Morris Goodman Cancer Institute
[3] Tianjin Medical University,School of Nursing
来源：
Journal of Nanobiotechnology | / 20卷
关键词：
Nanoformulations; CRISPR-Cas9; Stimuli-responsive; Genome editing; External stimuli; Internal stimuli; Drug delivery;
D O I：
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学科分类号：
摘要：
The CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering strategies to enable efficient intracellular delivery of CRISPR-Cas9 components has been a central theme for broadening the impact of the CRISPR-Cas9 technology. Various non-viral delivery systems for CRISPR-Cas9 have been investigated given their favorable safety profiles over viral systems. Many recent efforts have been focused on the development of stimuli-responsive non-viral CRISPR-Cas9 delivery systems, with the goal of achieving efficient and precise genome editing. Stimuli-responsive nanoplatforms are capable of sensing and responding to particular triggers, such as innate biological cues and external stimuli, for controlled CRISPR-Cas9 genome editing. In this Review, we overview the recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlight the rationale of stimuli and formulation designs, and summarize their biomedical applications.
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[1]  
Strzyz P(2020)CRISPR–Cas9 wins Nobel Nat Rev Mol Cell Biol 21 714-714
[2]  
Hsu PD(2014)Development and applications of CRISPR-Cas9 for genome engineering Cell 157 1262-1278
[3]  
Lander ES(2022)CRISPR in cancer biology and therapy Nat Rev Cancer 22 59-677
[4]  
Zhang F(2020)Applications of CRISPR-Cas in agriculture and plant biotechnology Nat Rev Mol Cell Biol 21 661-941
[5]  
Katti A(2016)Applications of CRISPR technologies in research and beyond Nat Biotechnol 34 933-205
[6]  
Diaz BJ(2022)The use of new CRISPR tools in cardiovascular research and medicine Nat Rev Cardiol 19 505-250
[7]  
Caragine CM(2020)A CRISPR way for accelerating improvement of food crops Nature Food 1 200-311
[8]  
Sanjana NE(2021)Nanotechnology to advance CRISPR-Cas genetic engineering of plants Nat Nanotechnol 16 243-15
[9]  
Dow LE(2021)The trends in CRISPR research: a patent and literature study with a focus on India World Patent Inf 65 102038-395
[10]  
Zhu H(1911)The CRISPR tool kit for genome editing and beyond Nat Commun 2018 9-542
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