A Quantitative Structure-Property Relationship for Predicting Drug Solubility in PEG 400/Water Cosolvent Systems

被引：0
|
作者：
Erik Rytting
Kimberley A. Lentz
Xue-Qing Chen
Feng Qian
Srini Venkatesh
机构：
[1] Bristol-Myers Squibb Pharmaceutical Research Institute,Discovery Pharmaceutics, Preclinical Candidate Optimization
[2] Bristol-Myers Squibb Pharmaceutical Research Institute,Discovery Pharmaceutics, Preclinical Candidate Optimization
[3] University of Kansas,Department of Pharmaceutical Chemistry
来源：
Pharmaceutical Research | 2004年 / 21卷
关键词：
cosolvent; PEG 400; prediction; QSPR model; solubility;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Purpose. A quantitative structure-property relationship (QSPR) was developed to predict drug solubility in binary mixtures of polyethylene glycol (PEG) 400 and water. The ability of the QSPR model to predict solubility was assessed and compared to the classic log-linear cosolvency model.
引用
收藏
页码：237 / 244
页数：7
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