Biophysical response of living cells to boron nitride nanoparticles: uptake mechanism and bio-mechanical characterization

被引：0
作者：
Md. Alim Iftekhar Rasel
Tong Li
Trung Dung Nguyen
Sanjleena Singh
Yinghong Zhou
Yin Xiao
YuanTong Gu
机构：
[1] Queensland University of Technology (QUT),School of Chemistry, Physics and Mechanical Engineering
[2] Queensland University of Technology (QUT),Institute of Health and Biomedical Innovation
来源：
Journal of Nanoparticle Research | 2015年 / 17卷
关键词：
Boron nitride; Nanoparticles; Biomechanics; Cellular uptake mechanism; Cytotoxicity; Atomic force microscopy; Drug delivery vehicle;
D O I：
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中图分类号：
学科分类号：
摘要：
Boron nitride nanomaterials have attracted significant interest due to their superior chemical and physical properties. Despite these novel properties, investigation on the interaction between boron nitride nanoparticle (BN NP) and living systems has been limited. In this study, BN NP (100–250 nm) is assessed as a promising biomaterial for medical applications. The toxicity of BN NP is evaluated by assessing the cells behaviours both biologically (MTT assay, ROS detection etc.) and physically (atomic force microscopy). The uptake mechanism of BN NP is studied by analysing the alternations in cellular morphology based on cell imaging techniques. The results demonstrate in vitro cytocompatibility of BN NP with immense potential for use as an effective nanoparticle for various bio-medical applications.
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