Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

[1] Im KH(2018)Hyperlipidemic inhibitory effects of Phellinus pini in rats fed with a high fat and cholesterol diet Mycobiology 46 159-167

[2] Choi J(2012)Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII FEBS J 279 91-99

[3] Baek SA(2017)CRISPR/Cas9-mediated ApoE−/− and LDLR−/− double gene knockout in pigs elevates serum LDL-C and TC levels Oncotarget 8 37751-37760

[4] Wei J(2015)Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia Dis Model Mech 8 989-998

[5] Ouyang H(2017)Anti-atherosclerotic effect of hesperidin in LDLr(−/−) mice and its possible mechanism Eur J Pharmacol 815 109-117

[6] Wang Y(2016)ApoE knockout rabbits: a novel model for the study of human hyperlipidemia Atherosclerosis 245 187-193

[7] Huang L(2018)Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7 EBioMedicine 36 29-38

[8] Hua ZD(2018)Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments J Biotechnol 284 91-101

[9] Xiao HW(2013)Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European atherosclerosis society Eur Heart J 34 3478-3490

[10] Liu C(2018)Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia - a preliminary report Lipids Health Dis 17 100-1110

[1] Im KH(2018)Hyperlipidemic inhibitory effects of Phellinus pini in rats fed with a high fat and cholesterol diet Mycobiology 46 159-167

[2] Choi J(2012)Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII FEBS J 279 91-99

[3] Baek SA(2017)CRISPR/Cas9-mediated ApoE−/− and LDLR−/− double gene knockout in pigs elevates serum LDL-C and TC levels Oncotarget 8 37751-37760

[4] Wei J(2015)Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia Dis Model Mech 8 989-998

[5] Ouyang H(2017)Anti-atherosclerotic effect of hesperidin in LDLr(−/−) mice and its possible mechanism Eur J Pharmacol 815 109-117

[6] Wang Y(2016)ApoE knockout rabbits: a novel model for the study of human hyperlipidemia Atherosclerosis 245 187-193

[7] Huang L(2018)Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (LDLR) on exon 7 EBioMedicine 36 29-38

[8] Hua ZD(2018)Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments J Biotechnol 284 91-101

[9] Xiao HW(2013)Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European atherosclerosis society Eur Heart J 34 3478-3490

[10] Liu C(2018)Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia - a preliminary report Lipids Health Dis 17 100-1110