The Mannich reaction in the synthesis of N,S-containing heterocycles 11. Synthesis of 3,3′-(1,4-phenylene)-bis(8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazine-9-carbonitriles)

被引：0

作者：

V. V. Dotsenko

S. G. Krivokolysko

V. P. Litvinov

机构：

[1] “ChemEx“ Laboratory Vladimir Dal’ East-Ukrainian National University,Physico

[2] State Enterprise “Luganskstandartmetrology”,chemical Department

[3] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry

来源：

Russian Chemical Bulletin | 2012年 / 61卷

关键词：

the Mannich reaction; tetrahydropyridine-2-thiolates; aminomethylation; pyrido[2,1-; ][1,3,5]thiadiazines; three-component reaction;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

N-Methylmorpholinium 4-aryl-3-cyano-6-oxo-1,4,5,6-tetrahydropyridine-2-thiolates readily undergo the Mannich reaction with p-phenylenediamines and excess formaldehyde in the absence of a catalyst to form 3,3′-(1,4-phenylene)-bis(8-aryl-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazine-9-carbonitriles) in moderate yields (24–56%).

引用

页码：131 / 135

页数：4

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