Immunohistochemical study of metaplastic carcinoma and central acellular carcinoma of the breast: central acellular carcinoma is related to metaplastic carcinoma

被引:0
作者
Rin Yamaguchi
Maki Tanaka
Keiko Kondo
Toshiro Yokoyama
Ichiro Maeda
Shin-ichi Tsuchiya
Miki Yamaguchi
Ryuji Takahashi
Yutaka Ogata
Hideyuki Abe
Jun Akiba
Osamu Nakashima
Masayoshi Kage
Hirohisa Yano
机构
[1] Kurume University School of Medicine,Department of Pathology
[2] Kurume University Medical Center,Department of Surgery
[3] Kurume Daiichi Social Insurance Hospital,Department of Surgery
[4] Kurume University Medical Center,Department of Pathology
[5] Kurume University Hospital,Department of Diagnostic Pathology
[6] St. Marianna University School of Medicine,Department of Diagnostic Pathology
[7] Nippon Medical School,Department of Diagnostic Pathology
来源
Medical Molecular Morphology | 2012年 / 45卷
关键词
Breast; Central acellular carcinoma; Metaplastic carcinoma; Basal-like tumor; Triple negative; Ep-CAM; Myoepithelial differentiation;
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学科分类号
摘要
Metaplastic breast cancers (MBCs) [spindle cell carcinoma (SpCC), squamous cell carcinoma (SCC), and matrix-producing carcinoma (MPC)] and invasive carcinomas with central acellular zones (CACs) were analyzed with respect to biological potential by immunohistochemical analyses. Specimens from 40 patients [20 with MBCs (7 with SCC, 6 with SpCC, 5 with MPC, and 2 with mixed type)] and 20 with CACs were analyzed using antibodies to cytokeratin (CK) 8, 5/6, 14, AE1/AE3, 34αE12, involucrin, c-kit, vimentin (VIM), alpha-smooth muscle actin, p63, epidermal growth factor receptor, epithelial cell adhesion molecule, and estrogen receptor (ER)/progesterone receptor (PR)/HER2. Expression of CK5/6, 34βE12, VIM, nuclear p63, and cytoplasmic p63 was significantly higher with MBCs than CACs (38%/13%, 70%/43%, 85%/33%, 68%/40%, and 48%/18%, respectively). Other markers were expressed at various levels in these tumors, but the difference between them was not significant. Eighteen MBC and 8 CAC cases were triple (ER/PR/HER2) negative; 17 MBCs and 7 CACs were basal-like tumors. Several differences were seen in MBCs and CACs, but they were heterogeneous, differentiating multipotentially into mesenchymal, myoepithelial, basal-like phenotypes with “stem cell-like” features. Thus, CACs are related to MBCs by immunohistochemical analyses as well as according to morphological findings.
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页码:14 / 21
页数:7
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