MicroRNAs as biomarkers of cervical cancer development: a literature review on miR-125b and miR-34a

被引：0
作者：
Joana Ribeiro
Hugo Sousa
机构：
[1] University of Porto,Faculty of Medicine
[2] Portuguese Institute of Oncology of Porto,Virology Service
[3] Portuguese Institute of Oncology of Porto,Molecular Oncology Group
[4] Portuguese League Against Cancer,undefined
[5] Núcleo Regional do Norte,undefined
来源：
Molecular Biology Reports | 2014年 / 41卷
关键词：
Cervical cancer; HPV infection; miR-34a; miR-125b; Biomarkers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs are non-coding RNAs with important functions in several biological processes, such as, regulation of cell cycle, immune response, inflammation, and apoptosis. In fact, deregulation and abnormal expression of these molecules is associated with human pathologies including cancer and several have already emerged as potential prognostic biomarkers in different neoplasias. miR-34a is directly regulated by p53 and acts as tumor suppressor while miR-125b plays a significant role in immune response and apoptosis. In cervical carcinogenesis, HPV proteins seem to interact with both miR-34a and miR-125b changing its expression and promoting persistent infection and cervical cancer development. In this review we describe the potential role of miR-125b and miR-34a in cervical carcinogenesis, including interaction with HPV and mechanism of deregulation. Additionally, their clinical applications in cervical cancer as prognostic/predictive biomarkers are also briefly discussed.
引用
收藏
页码：1525 / 1531
页数：6
相关论文
共 91 条
  • [41] Martinez I(2010)Specific microRNAs are downregulated in human thyroid anaplastic carcinomas J Biol Chem 285 21496-752
  • [42] Nambaru L(2013)MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression Oncogene 32 3071-8438
  • [43] Wang X(2007)MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R J Biol Chem 282 1479-38
  • [44] Li BH(2012)Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b Mem Inst Oswaldo Cruz 107 824-1128
  • [45] Li Y(2012)Upregulation of hsa-miR-125b in HTLV-1 asymptomatic carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis patients Retrovirology 9 5-322
  • [46] Greco D(2010)Relationships of PBMC microRNA expression, plasma viral load, and CD4+ T-cell count in HIV-1-infected elite suppressors and viremic patients Diagn Mol Pathol 19 135-647
  • [47] O’Connell RM(2007)Strong inverse correlation between microRNA-125b and human papillomavirus DNA in productive infection Curr Biol 17 1298-604
  • [48] Zhao JL(2007)p53-mediated activation of miRNA34 candidate tumor-suppressor genes Mol Cell 26 745-7722
  • [49] Rao DS(2007)Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis Cancer Res 67 8433-906
  • [50] Jia HY(2012)MicroRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth Lung Cancer 76 32-660
12345678910