Lung adenocarcinoma with Lambert-Eaton myasthenic syndrome indicated by voltage-gated calcium channel: A case report

被引：7

作者：

Arai H. ^{[1
]}

Inui K. ^{[1
]}

Hashimoto K. ^{[1
]}

Kan-O K. ^{[1
]}

Nishii T. ^{[1
]}

Kishida H. ^{[2
]}

Okudela K. ^{[5
]}

Tsuboi M. ^{[1
]}

Nozawa A. ^{[3
]}

Kaneko T. ^{[1
]}

Masuda M. ^{[4
]}

机构：

[1] Respiratory Disease Center, Yokohama City University Medical Center, Minami-ku, Yokohama 232-0024

[2] Department of Neurology, Yokohama City University Medical Center, Minami-ku, Yokohama 232-0024

[3] Department of Pathology, Yokohama City University Medical Center, Minami-ku, Yokohama 232-0024

[4] Department of Surgery, Yokohama City University, Graduate School of Medicine, Kanazawa-ku, Yokohama 236-0004

[5] Department of Pathology, Yokohama City University, Graduate School of Medicine, Kanazawa-ku, Yokohama 236-0004

来源：

Journal of Medical Case Reports | / 6卷 / 1期

关键词：

Immunostaining; Lambert-Eaton myasthenic syndrome; Lung adenocarcinoma; Voltage-gated calcium channel;

D O I：

10.1186/1752-1947-6-281

中图分类号：

学科分类号：

摘要：

Introduction. Lambert-Eaton myasthenic syndrome is a rare disorder and it is known as a paraneoplastic neurological syndrome. Small cell lung cancer often accompanies this syndrome. Lambert-Eaton myasthenic syndrome associated with lung adenocarcinoma is extremely rare; there are only a few reported cases worldwide. Case presentation. A 75-year-old Japanese man with a past history of chronic rheumatoid arthritis and Sjögren syndrome was diagnosed with Lambert-Eaton myasthenic syndrome by electromyography and serum anti-P/Q-type voltage-gated calcium channel antibody level preceding the diagnosis of lung cancer. A chest computed tomography to screen for malignant lesions revealed an abnormal shadow in the lung. Although a histopathological examination by bronchoscopic study could not reveal the malignancy, lung cancer was mostly suspected after the results of a chest computed tomography and [ 18F]-fluorodeoxyglucose positron emission tomography. An intraoperative diagnosis based on the frozen section obtained by tumor biopsy was adenocarcinoma so the patient underwent a lobectomy of the right lower lobe and lymph node dissection with video-assisted thoracoscopic surgery. The permanent pathological examination was the same as the frozen diagnosis (pT2aN1M0: Stage IIa: TNM staging 7th edition). Immunohistochemistry revealed that most of the cancer cells were positive for P/Q-type voltage-gated calcium channel. Conclusions: Our case is a rare combination of Lambert-Eaton myasthenic syndrome associated with lung adenocarcinoma, rheumatoid arthritis and Sjögren syndrome, and to the best of our knowledge it is the first report that indicates the presence of voltage-gated calcium channel in lung adenocarcinoma by immunostaining. © 2012 Arai et al.; licensee BioMed Central Ltd.

引用

共 12 条

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