High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

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作者
Sehui Kim
Jaemoon Koh
Seung Geun Song
Jeemin Yim
Miso Kim
Bhumsuk Keam
Young Tae Kim
Jihun Kim
Doo Hyun Chung
Yoon Kyung Jeon
机构
[1] Seoul National University College of Medicine,Department of Pathology
[2] Yonsei University College of Medicine,Department of Pathology
[3] Seoul National University College of Medicine,Department of Biomedical Sciences
[4] Seoul National University College of Medicine,Department of Internal Medicine
[5] Seoul National University Hospital,Department of Thoracic Surgery
[6] Seoul National University College of Medicine,Department of Pathology, Asan Medical Center
[7] Seoul National University Cancer Research Institute,undefined
[8] University of Ulsan College of Medicine,undefined
来源
BMC Cancer | / 22卷
关键词
Hexokinase-2; Glycolysis; Tumor microenvironment; Tumor-infiltrating lymphocytes; CD8 + T-cell to Treg ratio; Immunotherapy;
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