Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice

被引:0
作者
Francesca Stabile
G. Torromino
S. Rajendran
G. Del Vecchio
C. Presutti
C. Mannironi
E. De Leonibus
A. Mele
A. Rinaldi
机构
[1] Sapienza University of Rome,Department of Biology and Biotechnologies “Charles Darwin” (BBCD)
[2] Sapienza University of Rome,Centre for Research in Neurobiology Daniel Bovet (CRiN)
[3] University of Naples Federico II,Department of Humanistic Studies
[4] Sapienza University of Rome,Institute of Molecular Biology and Pathology, c/o Department of Biology and Biotechnology, National Research Council
[5] National Research Council (IBBC-CNR),Institute of Biochemistry and Cell Biology
[6] Telethon Institute of Genetics and Medicine (TIGEM),undefined
来源
Molecular Neurobiology | 2024年 / 61卷
关键词
High-load short-term memory; Ageing; MicroRNAs; miR-153-3p; Hippocampus;
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中图分类号
学科分类号
摘要
The early stages of ageing are a critical time window in which the ability to detect and identify precocious molecular and cognitive markers can make the difference in determining a healthy vs unhealthy course of ageing. Using the 6-different object task (6-DOT), a highly demanding hippocampal-dependent recognition memory task, we classified a population of middle-aged (12-month-old) CD1 male mice in Impaired and Unimpaired based on their short-term memory. This approach led us to identify a different microRNAs expression profile in the hippocampus of Impaired mice compared to Unimpaired ones. Among the dysregulated microRNAs, miR-153-3p was upregulated in the hippocampus of Impaired mice and appeared of high interest for its putative target genes and their possible implication in memory-related synaptic plasticity. We showed that intra-hippocampal injection of the miR-153-3p mimic in adult (3-month-old) mice is sufficient to induce a short-term memory deficit similar to that observed in middle-aged Impaired mice. Overall, these findings unravel a novel role for hippocampal miR-153-3p in modulating short-term memory that could be exploited to prevent early cognitive deficits in ageing.
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页码:3031 / 3041
页数:10
相关论文
共 117 条
[1]  
López-Otín C(2023)Hallmarks of aging: an expanding universe Cell 186 243-278
[2]  
Blasco MA(2019)State of the science on mild cognitive impairment (MCI) CNS Spectr 24 78-87
[3]  
Partridge L(1999)Mild cognitive impairment Arch Gen Psychiatry 56 303-308
[4]  
Anderson ND(1956)The magical number seven, plus or minus two: some limits on our capacity for processing information Psychol Rev 63 81-97
[5]  
Petersen RC(2001)The magical number 4 in short-term memory: a reconsideration of mental storage capacity Behav Brain Sci 24 87-114
[6]  
Smith GE(2017)Novel object recognition test for the investigation of learning and memory in mice J Vis Exp 2017 1-9
[7]  
Waring SC(1999)Hippocampal formation lesions produce memory impairment in the rhesus monkey Hippocampus 9 562-574
[8]  
Miller GA(2012)Role of the dorsal hippocampus in object memory load Learn Mem 19 211-218
[9]  
Cowan N(2000)The episodic buffer: a new component of working memory? Trends Cogn Sci 4 417-423
[10]  
Lueptow LM(2018)Working memory from the psychological and neurosciences perspectives: a review Front Psychol 9 1-16