Stem cell-derived exosomes for chronic wound repair

被引：0
作者：
Peng Mi
Jia-Lin Liu
Bao-Ping Qi
Ben-Mei Wei
Cheng-Zhi Xu
Lian Zhu
机构：
[1] Wuhan Polytechnic University,School of Chemistry and Environmental Engineering
[2] Changqing Garden,Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases
[3] Hubei Minzu University,School of Chemistry and Environmental Engineering
[4] Enshi,undefined
[5] Hubei Minzu University,undefined
来源：
Cell and Tissue Research | 2023年 / 391卷
关键词：
Stem cells; Exosomes; Chronic wound; Inflammation; Angiogenesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Stem cells possess the capability of self-renewal and multipotency, which endows them with great application potential in wound repair fields. Yet, several problems including immune concerns, ethical debates, and oncogenicity impede the broad and deep advance of stem cell-based products. Recently, owing to their abundant resources, excellent biocompatibility, and ease of being engineered, stem cell-derived exosomes were proved to be promising nanomedicine for curing chronic wounds. What is more, stem cell-derived exosomes are almost the mini record of their maternal cells, which even equipped them with the unique characteristics of stem cells. Chronic wound healing efficacy is dominated by several complicated factors, especially the excessive inflammation conditions and impaired vessels. Therefore, this review tries to concentrate on the current advances of stem cell-derived exosomes for reducing inflammation and promoting angiogenesis in chronic wound healing processes. Last but not least, the existing limitations and future perspectives of stem cell-derived exosomes for chronic wound treatment are also outlined.
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页码：419 / 423
页数：4
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