Brn-3a neuronal transcription factor functional expression in human prostate cancer

被引：0
|
作者：
J K J Diss
D J Faulkes
M M Walker
A Patel
C S Foster
V Budhram-Mahadeo
M B A Djamgoz
D S Latchman
机构：
[1] Medical Molecular Biology Unit,Department of Histopathology
[2] Institute of Child Health,Department of Urology
[3] University College London,Department of Cellular and Molecular Pathology
[4] Imperial College School of Medicine,Department of Biological Sciences
[5] St Mary's Hospital,undefined
[6] Imperial College School of Medicine,undefined
[7] St Mary's Hospital,undefined
[8] University of Liverpool,undefined
[9] Neuroscience Solutions to Cancer Research Group,undefined
[10] Imperial College London,undefined
[11] Birkbeck College,undefined
[12] University of London,undefined
来源：
Prostate Cancer and Prostatic Diseases | 2006年 / 9卷
关键词：
Brn-3; real-time PCR; immunohistochemistry; growth; Nav1.7;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor in vitro (i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.
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页码：83 / 91
页数：8
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