Growth hormone releasing hormone in the unfolded protein response context

被引：0
作者：
Nektarios Barabutis
机构：
[1] University of Louisiana Monroe,School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy
来源：
Endocrine | 2020年 / 67卷
关键词：
Inflammation; P53; Endothelium;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effects of Growth Hormone Releasing Hormone in human pathophysiology are not limited to those mediated by the Growth Hormone Releasing Hormone–Growth Hormone–Insulin-like Growth Factor-I axis. Receptors specific for this neuropeptide are expressed in a diverse variety of human tissues, to initiate multifarious signaling cascades, regulators of cellular homeostasis and survival. The Unfolded Protein Response is in charge of adaptive responses towards a plethora of challenges, able to trigger cellular repair or death. The possible involvement of Growth Hormone Releasing Hormone and its agonistic and antagonistic analogs in those events, may deliver exciting possibilities in the treatment of human disease, including the Acute Respiratory Distress Syndrome.
引用
收藏
页码：291 / 293
页数：2
相关论文
共 175 条
  • [1] Schally AV(1969)Isolation of growth hormone-releasing hormone(GRH) from porcine hypothalami Endocrinology 84 1493-1506
  • [2] Sawano S(1992)Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone Mol. Endocrinol. 6 1734-1744
  • [3] Arimura A(2006)Differential regulation of GHRH-receptor and GHS-receptor expression by long-term in vitro treatment of ovine pituitary cells with GHRP-2 and GHRH Endocrine 30 55-62
  • [4] Barrett JF(1999)Molecular and cell biology of the growth hormone-releasing hormone receptor Growth Horm. IGF Res. 9 37-44
  • [5] Wakabayashi I(2005)The expression of the pituitary growth hormone-releasing hormone receptor and its splice variants in normal and neoplastic human tissues Proc. Natl Acad. Sci. USA 102 17424-17429
  • [6] Bowers CY(2000)Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers Proc. Natl Acad. Sci. USA 97 10561-10566
  • [7] Mayo KE(2003)Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor Proc. Natl Acad. Sci. USA 100 9512-9517
  • [8] Roh SG(2007)Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormone-releasing hormone receptor Proc. Natl Acad. Sci. USA 104 5575-5579
  • [9] Doconto M(2019)Actions and potential therapeutic applications of growth hormone-releasing hormone agonists Endocrinology 160 1600-1612
  • [10] Feng DD(2008)Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer Nat. Clin. Pract. Endocrinol. Metab. 4 33-43
12345678910