The drug-transporter gene MDR1 C3435T and G2677T/A polymorphisms and the risk of multidrug-resistant epilepsy in Turkish children

被引:0
作者
Mehmet Seven
Bahadir Batar
Selin Unal
Gozde Yesil
Adnan Yuksel
Mehmet Guven
机构
[1] Istanbul University,Department of Medical Genetics, Cerrahpasa Medical Faculty
[2] Istanbul University,Department of Medical Biology, Cerrahpasa Medical Faculty
来源
Molecular Biology Reports | 2014年 / 41卷
关键词
Drug resistance; Epilepsy; MDR1; P-gp; Polymorphism;
D O I
暂无
中图分类号
学科分类号
摘要
One-third of all individuals with epilepsy are resistant to antiepileptic drug (AED) treatment. Antiepileptic treatment response has been suggested to be modulated by genetic polymorphisms of drug efflux transporters. Several polymorphic variants within the multidrug resistance 1 (MDR1) gene, which encodes the major transmembrane efflux transporter P-glycoprotein, have been proposed to be associated with AED resistance in epilepsy patients. The aim of this study was to evaluate the effect of C3435T and G2677T/A polymorphisms of MDR1 on AED resistance in Turkish children with epilepsy. MDR1 C3435T and G2677T/A were genotyped in 152 patients with epilepsy, classified as drug-resistant in 69 and drug-responsive in 83. Genotypes of the C3435T and G2677T/A polymorphisms were determined by polymerase chain reaction followed by restriction fragment length polymorphism. Genotype and allele frequencies of C3435T and G2677T/A polymorphisms of the MDR1 gene did not differ between drug-resistant and drug-responsive epilepsy patients. Our results suggest that MDR1 C3435T and G2677T/A polymorphisms are not associated with AED resistance in Turkish epileptic patients. To clarify the exact clinical implication of the MDR1 polymorphisms on the multidrug resistance in epilepsy, further investigations in various ethnic populations would be necessary.
引用
收藏
页码:331 / 336
页数:5
相关论文
共 50 条
[31]   Impact of MDR1 haplotypes derived from C1236T, G2677T/A and C3435T on the pharmacokinetics of single-dose oral digoxin in healthy chinese volunteers [J].
Xu, Ping ;
Jiang, Zhi-Ping ;
Zhang, Bi-Kui ;
Tu, Ji-Ying ;
Li, Huan-De .
PHARMACOLOGY, 2008, 82 (03) :221-227
[32]   The significance of T129C and G2677T polymorphism of the MDR1 gene in ovarian cancer patients [J].
Kufelnicka-Babout, Maja ;
Smolarz, Beata ;
Kulig, Andrzej ;
Szpakowski, Marian ;
Wilczynski, Jacek R. .
MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY, 2008, 7 (06) :295-300
[33]   Role of ABCB1 C1236T, G2677T, and C3435T genetic polymorphisms in the development of acute leukemia in a Chinese population [J].
Feng, R. ;
Zhang, H. X. ;
Zhang, H. G. ;
Zhang, C. F. .
GENETICS AND MOLECULAR RESEARCH, 2016, 15 (03)
[34]   MDR1 gene C3435T polymorphism and the risk of acquired aplastic anaemia [J].
Calado, RT ;
Franco, RF ;
Zago, MA ;
Falcao, RP .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 117 (03) :769-770
[35]   C3435T polymorphism of MDR1 gene with warfarin resistance [J].
Kim, Yeongsic ;
Smith, Andrew ;
Wu, Alan H. B. .
CLINICA CHIMICA ACTA, 2013, 425 :34-36
[36]   Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone [J].
Pawlik, A ;
Baskiewicz-Masiuk, M ;
Machalinski, B ;
Kurzawski, M ;
Gawronska-Szklarz, B .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 528 (1-3) :27-36
[37]   Relationship between the C3435T and G2677T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver [J].
Owen, A ;
Goldring, C ;
Morgan, P ;
Chadwick, D ;
Park, BK ;
Pirmohamed, M .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2005, 59 (03) :365-370
[38]   Analysis of common MDR1 (ABCB1) gene C1236T and C3435T polymorphisms in Turkish patients with familial Mediterranean fever [J].
Rustemoglu, A. ;
Gumus-Akay, G. ;
Yigit, S. ;
Tasliyurt, T. .
GENETICS AND MOLECULAR RESEARCH, 2011, 10 (04) :3411-3420
[39]   MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome [J].
Cizmarikova, M. ;
Wagnerova, M. ;
Schonova, L. ;
Habalova, V. ;
Kohut, A. ;
Linkova, A. ;
Sarissky, M. ;
Mojzis, J. ;
Mirossay, L. ;
Mirossay, A. .
PHARMACOGENOMICS JOURNAL, 2010, 10 (01) :62-69
[40]   Association of MDR1 gene C3435T polymorphism with childhood intractable epilepsy: a meta-analysis [J].
Sun, Guilian ;
Sun, Xue ;
Guan, Limei .
JOURNAL OF NEURAL TRANSMISSION, 2014, 121 (07) :717-724