Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine

被引：1
作者：
Sivapatham Sundaresan
Perumal Subramanian
机构：
[1] Annamalai University,Department of Biochemistry and Biotechnology, Faculty of Science
来源：
Molecular and Cellular Biochemistry | 2008年 / 310卷
关键词：
Antioxidants; Hepatocarcinogenesis; Lipid peroxidation; Nitrosodiethylamine; -allylcysteine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemopreventive effect of S-allylcysteine (constituent of garlic) on N-nitrosodiethylamine (NDEA)-induced hepatocarcinogenesis was evaluated in Wistar rats. Significantly decreased lipid peroxidation products (thiobarbituric acid reactive substances-TBARS and lipid hydroperoxides) with increased level of reduced glutathione, increased activities of glutathione S-transferase, and glutathione peroxidase were observed in liver of NDEA-treated rats when compared with control rats. The activities of superoxide dismutase and catalase were significantly decreased in tumor tissue when compared with control. Administration of S-allylcysteine (SAC) showed the inhibition of tumor incidence, modulated the lipid peroxidation, and increased the reduced glutathione, glutathione-dependent enzymes, superoxide dismutase, and catalase in NDEA-induced carcinogenesis. From our results, we speculate that S-allylcysteine mediates its chemopreventive effects by modulating lipid peroxidation, GST stimulation, and by increasing the antioxidants. Hence SAC prevents cells from loss of oxidative capacity in NDEA-induced hepatocarcinogenesis.
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页码：209 / 214
页数：5
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