Steered Molecular Dynamics Simulation Study of Quantified Effects of Point Mutation Induced by Breast Cancer on Mechanical Behavior of E-Cadherin

被引:0
作者
Sh. Azadi
M. Tafazzoli-Shadpour
R. Omidvar
机构
[1] Faculty of Biomedical Engineering,
[2] Amirkabir University of Technology,undefined
来源
Molecular Biology | 2018年 / 52卷
关键词
steered molecular dynamics; point mutation; breast cancer; stiffness; protein stability;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:723 / 731
页数:8
相关论文
共 202 条
  • [1] Patel S.D.(2003)Cadherin-mediated cell–cell adhesion: Sticking together as a family Curr. Opin. Struct. Biol. 13 690-698
  • [2] Chen C.P.(2009)Molecular evolution of the cadherin superfamily Int. J. Biochem. Cell Biol. 41 349-369
  • [3] Bahna F.(2009)Structure and biochemistry of cadherins and catenins Cold. Spring. Harb. Perspect. Biol. 1 a003053-26
  • [4] Honig B.(1994)Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness Biochim. Biophys. Acta 1198 11-252
  • [5] Shapiro L.(1990)Cadherins: A molecular family important in selective cell–cell adhesion Annu. Rev. Biochem. 59 237-4796
  • [6] Hulpiau P.(2000)Expression of E-cadherin and β‑catenin in human non-small cell lung cancer and the clinical significance Clin. Cancer. Res. 6 4789-237
  • [7] van Roy F.(1998)Mutations of the human E-cadherin ( Hum. Mutat. 12 226-1039
  • [8] Shapiro L.(1994)) gene Jpn. J. Cancer. Res. 85 1035-1977
  • [9] Weis W.I.(1998)Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast Cancer Res. 58 1972-1148
  • [10] Birchmeier W.(2007)Mechanisms of inactivation of E-cadherin in breast cancer cell lines Breast Cancer Res 9 R5-53