Streptomyces diastaticus isolated from the marine crustacean Portunus sanguinolentus with potential antibiofilm activity against Candida albicans

被引：0
作者：
Seema Siddharthan
Beema Shafreen Rajamohamed
Vinothini Gopal
机构：
[1] Sathyabama Institute of Science and Technology,Molecular and Nanomedicine Research Unit, Center for Nanoscience and Nanotechnology
[2] Alagappa University,Department of Biotechnology
[3] Science Campus,Department of Microbiology
[4] Bharathidasan University,undefined
来源：
Archives of Microbiology | 2020年 / 202卷
关键词：
Biofilm; FTIR; GC–MS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Biofilm-mediated multidrug resistance has turned into major challenge for the treatment of C. albicans infections. In the present study, actinomycetes (SS5) isolated from marine crustacean were investigated for their ability to inhibit C. albicans biofilm formation. Cultural, morphological and 16S rRNA analysis revealed that the isolated strain was Streptomyces diastaticus. Ethyl acetate bioactive fractions (6 µg mL−1) from SS5 showed potent antibiofilm activity against C. albicans. Light microscopic and CLSM analysis further substantiated the antibiofilm activity of the bioactive fraction against C. albicans. The bioactive fraction was subjected to FTIR and GC–MS for characterization. From GC–MS analysis, the presence of 31 compounds were revealed, among which the alkanes are predominantly present. Hence, further investigation for the potential of these bioactive compounds against C. albicans biofilm will help in the identification of promising candidate for the prevention of biofilm-mediated infection.
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页码：1977 / 1984
页数：7
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