Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B

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作者：
Jakub Suchodolski
Daria Derkacz
Przemysław Bernat
Anna Krasowska
机构：
[1] University of Wroclaw,Department of Biotransformation, Faculty of Biotechnology
[2] University of Łódź,Department of Industrial Microbiology and Biotechnology, Faculty of Biology and Environmental Protection
来源：
Scientific Reports | / 11卷
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摘要：
The effect of capric acid, secreted by the probiotic yeasts Saccharomyces boulardii, was evaluated on the activities of fluconazole (FLC) and amphotericin B (AMB) against pathogenic Candida albicans fungus. The findings indicated that capric acid may be a promising additive for use in combination with FLC. A FLC-capric acid combination led to reduced efflux activity of multidrug resistance (MDR) transporter Cdr1p by causing it to relocalize from the plasma membrane (PM) to the interior of the cell. The above effect occurred due to inhibitory effect of FLC-capric acid combination of ergosterol biosynthesis. However, capric acid alone stimulated ergosterol production in C. albicans, which in turn generated cross resistance towards AMB and inhibited its action (PM permeabilization and cytoplasm leakage) against C. albicans cells. This concluded that AMB should not be administered among dietary supplements containing capric acid or S. boulardii cells.
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  • [1] Puel A(2011)Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity Science (80-) 332 65-68
  • [2] Whaley SG(2017)Azole antifungal resistance in Front. Microbiol. 7 2173-138
  • [3] Dadar M(2018) and emerging non-albicans Candida Species Microb. Pathog. 117 128-19
  • [4] Alizadeh F(2017) - Biology, molecular characterization, pathogenicity, and advances in diagnosis and control – An update Curr. Med. Mycol. 3 13-1191
  • [5] Khodavandi A(2018)Quantitation of ergosterol content and gene expression profile of ERG11 gene in fluconazole-resistant Future Microbiol. 13 1175-259
  • [6] Zalakian S(2018)Responding to the emergence of antifungal drug resistance: perspectives from the bench and the bedside Adv. Biotechnol. Microbiol. 10 555777-6
  • [7] Beardsley J(2017)Antifungal resistance and its evolution: an increasing concern Infect. Drug Resist. 10 249-2239
  • [8] Halliday CL(2017)Antifungal resistance: current trends and future strategies to combat FEMS Yeast Res. 17 1-966
  • [9] Chen SCA(2014)A newly identified amino acid substitution T123I in the 14α-demethylase (Erg11p) of Front. Physiol. 5 143-203
  • [10] Sorrell TC(2012) confers azole resistance Proc. Natl. Acad. Sci. U. S. A. 109 2234-814
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