The influence of storage conditions on the polymorphic stability of zolpidem tartrate hydrate

被引：0
|
作者：
M. Ławecka
B. Kosmacińska
M. Glice
K. Korczak
机构：
[1] Pharmaceutical Research Institute,
来源：
Journal of Thermal Analysis and Calorimetry | 2006年 / 83卷
关键词：
drug substance; DSC; infrared spectroscopy (IR); polymorphic stability; thermogravimetric analysis (TG/SDTA); X-ray powder diffraction (XRPD); zolpidem tartrate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The polymorphic stability of a drug substance is a very important topic in the pharmaceutical industry. Differential scanning calorimetry, thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for testing structural changes of zolpidem tartrate hydrate stored under different conditions. Obtained data suggested that first structural changes occurred at the temperature of 25°C after 2 months of storage. DSC analysis showed that there was a two-step process of water elimination and lack of a phase transition in the temperature range from 130 to 170°C in comparison with an initial sample.
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页码：583 / 585
页数：2
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