Emerging role of liver X receptors in cardiac pathophysiology and heart failure

被引：0
作者：
Megan V. Cannon
Wiek H. van Gilst
Rudolf A. de Boer
机构：
[1] University of Groningen,Department of Cardiology
[2] University Medical Center Groningen,undefined
来源：
Basic Research in Cardiology | 2016年 / 111卷
关键词：
Cardiac remodeling; Cardiovascular risk factors; Heart failure; Hypertrophy; Liver X receptors; Metabolism;
D O I：
暂无
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学科分类号：
摘要：
Liver X receptors (LXRs) are master regulators of metabolism and have been studied for their pharmacological potential in vascular and metabolic disease. Besides their established role in metabolic homeostasis and disease, there is mounting evidence to suggest that LXRs may exert direct beneficial effects in the heart. Here, we aim to provide a conceptual framework to explain the broad mode of action of LXRs and how LXR signaling may be an important local and systemic target for the treatment of heart failure. We discuss the potential role of LXRs in systemic conditions associated with heart failure, such as hypertension, diabetes, and renal and vascular disease. Further, we expound on recent data that implicate a direct role for LXR activation in the heart, for its impact on cardiomyocyte damage and loss due to ischemia, and effects on cardiac hypertrophy, fibrosis, and myocardial metabolism. Taken together, the accumulating evidence supports the notion that LXRs may represent a novel therapeutic target for the treatment of heart failure.
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