Piezo2 is the major transducer of mechanical forces for touch sensation in mice

被引：0

作者：

Sanjeev S. Ranade

Seung-Hyun Woo

Adrienne E. Dubin

Rabih A. Moshourab

Christiane Wetzel

Matt Petrus

Jayanti Mathur

Valérie Bégay

Bertrand Coste

James Mainquist

A. J. Wilson

Allain G. Francisco

Kritika Reddy

Zhaozhu Qiu

John N. Wood

Gary R. Lewin

Ardem Patapoutian

机构：

[1] Howard Hughes Medical Institute,Department of Neuroscience

[2] Molecular and Cellular Neuroscience,undefined

[3] Dorris Neuroscience Center,undefined

[4] The Scripps Research Institute,undefined

[5] Max-Delbrück Center for Molecular Medicine,undefined

[6] Robert-Rössle Straße 10,undefined

[7] D-13092 Berlin,undefined

[8] Germany,undefined

[9] Klinik für Anästhesiologie mit Schwerpunkt Operative Intensivmedizin,undefined

[10] Campus Charité Mitte and Virchow-Klinikum Charité,undefined

[11] Universitätsmedizin Berlin,undefined

[12] Augustburgerplatz 1,undefined

[13] 13353 Berlin,undefined

[14] Germany,undefined

[15] Genomics Institute of the Novartis Research Foundation,undefined

[16] Molecular Nociception Group,undefined

[17] Wolfson Institute for Biomedical Research,undefined

[18] University College London,undefined

[19] London WC1E 6BT,undefined

[20] UK,undefined

[21] Present address: Ion Channels and Sensory Transduction group,undefined

[22] Aix Marseille University,undefined

[23] CNRS,undefined

[24] CRN2M-UMR 7286,undefined

[25] 13344 Marseille,undefined

[26] France.,undefined

来源：

Nature | 2014年 / 516卷

关键词：

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学科分类号：

摘要：

Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

引用

页码：121 / 125

页数：4

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