Piezo2 is the major transducer of mechanical forces for touch sensation in mice

被引：0

作者：

Sanjeev S. Ranade

Seung-Hyun Woo

Adrienne E. Dubin

Rabih A. Moshourab

Christiane Wetzel

Matt Petrus

Jayanti Mathur

Valérie Bégay

Bertrand Coste

James Mainquist

A. J. Wilson

Allain G. Francisco

Kritika Reddy

Zhaozhu Qiu

John N. Wood

Gary R. Lewin

Ardem Patapoutian

机构：

[1] Howard Hughes Medical Institute,Department of Neuroscience

[2] Molecular and Cellular Neuroscience,undefined

[3] Dorris Neuroscience Center,undefined

[4] The Scripps Research Institute,undefined

[5] Max-Delbrück Center for Molecular Medicine,undefined

[6] Robert-Rössle Straße 10,undefined

[7] D-13092 Berlin,undefined

[8] Germany,undefined

[9] Klinik für Anästhesiologie mit Schwerpunkt Operative Intensivmedizin,undefined

[10] Campus Charité Mitte and Virchow-Klinikum Charité,undefined

[11] Universitätsmedizin Berlin,undefined

[12] Augustburgerplatz 1,undefined

[13] 13353 Berlin,undefined

[14] Germany,undefined

[15] Genomics Institute of the Novartis Research Foundation,undefined

[16] Molecular Nociception Group,undefined

[17] Wolfson Institute for Biomedical Research,undefined

[18] University College London,undefined

[19] London WC1E 6BT,undefined

[20] UK,undefined

[21] Present address: Ion Channels and Sensory Transduction group,undefined

[22] Aix Marseille University,undefined

[23] CNRS,undefined

[24] CRN2M-UMR 7286,undefined

[25] 13344 Marseille,undefined

[26] France.,undefined

来源：

Nature | 2014年 / 516卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

引用

页码：121 / 125

页数：4

共 50 条

[31] A role for Piezo2 in EPAC1-dependent mechanical allodynia
Eijkelkamp, N.
Linley, J. E.
Torres, J. M.
Bee, L.
Dickenson, A. H.
Gringhuis, M.
Minett, M. S.
Hong, G. S.
Lee, E.
Oh, U.
Ishikawa, Y.
Zwartkuis, F. J.
Cox, J. J.
Wood, J. N.
NATURE COMMUNICATIONS, 2013, 4
[32] Piezo2 voltage-block regulates mechanical pain sensitivity
Saenchez-Carranza, Oscar
Chakrabarti, Sampurna
Kuehnemund, Johannes
Schwaller, Fred
Beegay, Valerie
Garcia-Contreras, Jonathan Alexis
Wang, Lin
Lewin, Gary R.
BRAIN, 2024, 147 (10) : 3487 - 3500
[33] Phenotypic characterization of mice lacking Piezo1 and/or Piezo2 in Col2a1-expressing cells
Brylka, Laura J.
Tschaffon-Mueller, Miriam E. A.
von Kroge, Simon
Schoppa, Astrid
Haffner-Luntzer, Melanie
Eghbalian, Kian M.
Pawlus, Eva
Yorgan, Timur A.
Amling, Michael
Ignatius, Anita
Schinke, Thorsten
JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 306 - 306
[34] Nociceptor Neurons Facilitate Orthodontic Tooth Movement via Piezo2 in Mice
Wang, S.
Nie, X.
Parastooei, G.
Kumari, S.
Abbasi, Y.
Elnabawi, O.
Pae, E. -k.
Ko, C. C.
Chung, M. -k.
JOURNAL OF DENTAL RESEARCH, 2025,
[35] PIEZO2 mediates injury-induced tactile pain in mice and humans
Szczot, Marcin
Liljencrantz, Jaquette
Ghitani, Nima
Barik, Arnab
Lam, Ruby
Thompson, James H.
Bharucha-Goebel, Diana
Saade, Dimah
Necaise, Aaron
Donkervoort, Sandra
Foley, A. Reghan
Gordon, Taylor
Case, Laura
Bushnell, M. Catherine
Bonnemann, Carsten G.
Chesler, Alexander T.
SCIENCE TRANSLATIONAL MEDICINE, 2018, 10 (462)
[36] Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity
Gabrielle, Matthew
Yudin, Yevgen
Wang, Yujue
Su, Xiaoyang
Rohacs, Tibor
NATURE COMMUNICATIONS, 2024, 15 (01)
[37] Margaric Acid Decreases Sensory Neurons Mechanical Excitability by Inhibiting PIEZO2 Channels
Romero, Luis O.
Cordero-Morales, Julio F.
Vasquez, Valeria
BIOPHYSICAL JOURNAL, 2020, 118 (03) : 397A - 398A
[38] PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice
Li, Jie
Liu, Shuang
Song, Chenmeng
Hu, Qun
Zhao, Zhikai
Deng, Tuantuan
Wang, Yi
Zhu, Tong
Zou, Linzhi
Wang, Shufeng
Chen, Jiaofeng
Liu, Lian
Hou, Hanqing
Yuan, Kexin
Zheng, Hairong
Liu, Zhiyong
Chen, Xiaowei
Sun, Wenzhi
Xiao, Bailong
Xiong, Wei
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (28)
[39] Oxytocin receptor expressing neurons utilize Piezo2 to mediate the baroreflex in female mice
Johnson, Dominique
Elsaafien, Khalid
Scott, Karen
de Kloet, Annette
Krause, Eric
PHYSIOLOGY, 2024, 39
[40] Upregulation of Piezo2 and increased extracellular matrix protein in diabetic kidney disease mice
Oba, Rina
Ueno, Hitoshi
Oishi, Atsuro
Nagahama, Kiyotaka
Kanzaki, Go
Tsuboi, Nobuo
Yokoo, Takashi
Nagase, Miki
HYPERTENSION RESEARCH, 2025, : 1514 - 1528

← 1 2 3 4 5 →