Piezo2 is the major transducer of mechanical forces for touch sensation in mice

被引：0

作者：

Sanjeev S. Ranade

Seung-Hyun Woo

Adrienne E. Dubin

Rabih A. Moshourab

Christiane Wetzel

Matt Petrus

Jayanti Mathur

Valérie Bégay

Bertrand Coste

James Mainquist

A. J. Wilson

Allain G. Francisco

Kritika Reddy

Zhaozhu Qiu

John N. Wood

Gary R. Lewin

Ardem Patapoutian

机构：

[1] Howard Hughes Medical Institute,Department of Neuroscience

[2] Molecular and Cellular Neuroscience,undefined

[3] Dorris Neuroscience Center,undefined

[4] The Scripps Research Institute,undefined

[5] Max-Delbrück Center for Molecular Medicine,undefined

[6] Robert-Rössle Straße 10,undefined

[7] D-13092 Berlin,undefined

[8] Germany,undefined

[9] Klinik für Anästhesiologie mit Schwerpunkt Operative Intensivmedizin,undefined

[10] Campus Charité Mitte and Virchow-Klinikum Charité,undefined

[11] Universitätsmedizin Berlin,undefined

[12] Augustburgerplatz 1,undefined

[13] 13353 Berlin,undefined

[14] Germany,undefined

[15] Genomics Institute of the Novartis Research Foundation,undefined

[16] Molecular Nociception Group,undefined

[17] Wolfson Institute for Biomedical Research,undefined

[18] University College London,undefined

[19] London WC1E 6BT,undefined

[20] UK,undefined

[21] Present address: Ion Channels and Sensory Transduction group,undefined

[22] Aix Marseille University,undefined

[23] CNRS,undefined

[24] CRN2M-UMR 7286,undefined

[25] 13344 Marseille,undefined

[26] France.,undefined

来源：

Nature | 2014年 / 516卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Mice lacking the mechanically activated ion channel Piezo2 in both sensory neurons and Merkel cells are almost totally incapable of light-touch sensation while other somatosensory functions, such as mechanical nociception, remain intact, implying that other mechanically activated ion channels must now be identified to account for painful touch sensation.

引用

页码：121 / 125

页数：4

共 50 条

[21] Piezo2 Integrates Mechanical and Thermal Cues in Vertebrate Mechanoreceptors
Nikolaev, Yury A.
Zheng, Wang
Gracheva, Elena O.
Bagriantsev, Sviatoslav N.
BIOPHYSICAL JOURNAL, 2020, 118 (03) : 396A - 396A
[22] Transduction of Repetitive Mechanical Stimuli by Piezo1 and Piezo2 Ion Channels
Lewis, Amanda H.
Cui, Alisa F.
McDonald, Malcolm F.
Grandl, Jorg
CELL REPORTS, 2017, 19 (12): : 2572 - 2585
[23] Piezo2 expression and its alteration by mechanical forces in mouse mesangial cells and renin-producing cells
Mochida, Yuki
Ochiai, Koji
Nagase, Takashi
Nonomura, Keiko
Akimoto, Yoshihiro
Fukuhara, Hiroshi
Sakai, Tatsuo
Matsumura, George
Yamaguchi, Yoshihiro
Nagase, Miki
SCIENTIFIC REPORTS, 2022, 12 (01)
[24] PIEZO2 is required for mechanotransduction in human ES-cell-derived touch receptors
Schrenk-Siemens, K.
Wende, H.
Prato, V.
Song, K.
Rostock, C.
Loewer, A.
Lewin, G. R.
Lechner, S. G.
Siemens, J.
ACTA PHYSIOLOGICA, 2016, 216
[25] PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors
Schrenk-Siemens, Katrin
Wende, Hagen
Prato, Vincenzo
Song, Kun
Rostock, Charlotte
Loewer, Alexander
Utikal, Jochen
Lewin, Gary R.
Lechner, Stefan G.
Siemens, Jan
NATURE NEUROSCIENCE, 2015, 18 (01) : 10 - +
[26] Piezo1 and Piezo2 foster mechanical gating of K2P channels
Glogowska, Edyta
Arhatte, Malika
Chatelain, Franck C.
Lesage, Florian
Xu, Aimin
Grashoff, Carsten
Discher, Dennis E.
Patel, Amanda
Honore, Eric
CELL REPORTS, 2021, 37 (09):
[27] A role for Piezo2 in EPAC1-dependent mechanical allodynia
N Eijkelkamp
J.E. Linley
J.M. Torres
L. Bee
A.H. Dickenson
M. Gringhuis
M.S. Minett
G.S. Hong
E. Lee
U. Oh
Y. Ishikawa
F.J. Zwartkuis
J.J. Cox
J.N. Wood
Nature Communications, 4
[28] Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch
Feng, Jing
Luo, Jialie
Yang, Pu
Du, Junhui
Kim, Brian S.
Hu, Hongzhen
SCIENCE, 2018, 360 (6388) : 530 - +
[29] Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Obeidat, Alia M.
Wood, Matthew J.
Adamczyk, Natalie S.
Ishihara, Shingo
Li, Jun
Wang, Lai
Ren, Dongjun
Bennett, David A.
Miller, Richard J.
Malfait, Anne-Marie
Miller, Rachel E.
NATURE COMMUNICATIONS, 2023, 14 (01)
[30] Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Alia M. Obeidat
Matthew J. Wood
Natalie S. Adamczyk
Shingo Ishihara
Jun Li
Lai Wang
Dongjun Ren
David A. Bennett
Richard J. Miller
Anne-Marie Malfait
Rachel E. Miller
Nature Communications, 14

← 1 2 3 4 5 →