Differential pulse voltammetry determination of acetaminophen and codeine in pharmaceutical formulations using a Mn/UiO-66 modified glassy carbon electrode

被引:0
作者
Tran Duc Manh
Vo Thang Nguyen
Vu Thi Duyen
Nguyen Thi Thy Nga
Nguyen Quang Man
Pham Thi Huyen Thoa
Le Huu Trinh
Dinh Quang Khieu
机构
[1] University of Education and Science,Faculty of Natural Science and Technology
[2] The University of Da Nang,Faculty of Science
[3] University of Medicine and Pharmacy,undefined
[4] Hue University,undefined
[5] Tay Nguyen University,undefined
[6] Nong Lam University,undefined
[7] University of Sciences,undefined
[8] Hue University,undefined
来源
Journal of Nanoparticle Research | 2023年 / 25卷
关键词
Acetaminophen; Codeine; Paracetamol; Mn/UiO-66; UiO-66; Nanostructures; Electrochemical sensor; Pharmaceutics;
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摘要
In the present paper, Mn/UiO-66 material was synthesized by hydrothermal process. The obtained material was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) with mapping and nitrogen adsorption/desorption techniques. The doped manganese was shown to highly disperse and might be grafted into the lattice of UiO-66. A simple, fast, and inexpensive differential pulse voltammetric (DPV) method were developed using Mn/UiO-66 as an electrode modifier for the simultaneous determination of acetaminophen (ACE) and codeine (CDE) in pharmaceutical formulations. The experimental parameters, which might affect the peak currents of ACE and CDE, such as the pH of the solution, accumulation time, and scan rate, were optimized. Under optimal conditions, this technique provided low limits of detection for the quantification of ACE and CDE, of 0.45 and 0.31 μM, respectively. The proposed DPV method was successfully applied to simultaneously determine ACE and CDE in samples of three pharmaceutical formulation with acceptable recoveries. Clearly, the proposed method might be an alternative option for the simultaneous determination of ACE and CDE.
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