Comparison of trans-fatty acids on proliferation and migration of vascular smooth muscle cells

被引:0
作者
Haewon Kim
Chang Hee Jeong
Hong Gu Lee
Sung Gu Han
机构
[1] Konkuk University,Department of Food Science and Biotechnology of Animal Resources
[2] Konkuk University,Department of Animal Science and Technology
来源
Food Science and Biotechnology | 2017年 / 26卷
关键词
trans-vaccenic acid; elaidic acid; vascular smooth muscle cell; proliferation; migration;
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中图分类号
学科分类号
摘要
Consumption of trans-fatty acids has been linked to an increased risk of cardiovascular diseases, such as atherosclerosis. Milk and dairy products contain trans-fatty acids, such as transvaccenic acid (TVA) and conjugated linoleic acid (CLA). Although artificially hydrogenated trans-fatty acids (e.g., elaidic acid (EA)) are known to induce atherosclerosis, it is unclear whether ruminant trans-fats, such as TVA, are associated with such diseases. Therefore, we investigated the effects of TVA on vascular smooth muscle cells (VSMCs). VSMCs were treated with TVA, CLA, and EA at 0-100 μM for 24 h. Cell proliferation and migration increased upon treatment with EA, not with TVA and CLA. EA increased protein expression of proliferation-associated proteins (cyclin-dependent kinase 4 (CDK4) and cyclin D1), while TVA and CLA decreased CDK4 expression. These results suggest that TVA is not as risky as other trans-fatty acids such as EA in the vascular system.
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页码:501 / 505
页数:4
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