Adipose-derived stem cells applied to ankle pathologies: a systematic review

被引：1
作者：
Arceri A. [1 ]
Mazzotti A. [1 ,2 ]
Artioli E. [1 ]
Zielli S.O. [1 ]
Barile F. [2 ]
Manzetti M. [1 ]
Viroli G. [1 ]
Ruffilli A. [1 ,2 ]
Faldini C. [1 ,2 ]
机构：
[1] 1st Orthopaedics and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Via Giulio Cesare Pupilli 1, Bologna
[2] Department of Biomedical and Neuromotor Sciences (DIBINEM), Alma Mater Studiorum University of Bologna, Bologna
来源：
MUSCULOSKELETAL SURGERY | 2024年 / 108卷 / 1期
关键词：
Adipose derived stem cells; Ankle; Osteoarthritis; Osteochondral lesions; Talus;
D O I：
10.1007/s12306-023-00798-7
中图分类号：
学科分类号：
摘要：
Abstract: The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the applications and results. A literature search of PubMed, Google Scholar, EMBASE and Cochrane Library database was performed. The review was conducted following PRISMA guidelines. Risk of bias assessment was conducted through the Methodological Index for Non-Randomized Studies (MINORS) criteria. Initial search results yielded 4348 articles. A total of 8 articles were included in the review process. No clinical evidence has demonstrated the effectiveness of one isolation method over the other, but nonenzymatic mechanical method has more advantages. In all studies included significant clinical outcomes improvement were recorded in patients affected by osteochondral lesion and osteoarthritis of ankle. All studies performed a concomitant procedure. No serious complications were reported. ADMSC injection, especially through the nonenzymatic mechanical methods, looks to be simple and promising treatment for osteochondral lesions and osteoarthritis of the ankle, with no severe complications. The current scarcity of studies and their low-quality level preclude definitive conclusions presently. Level of evidence: III. © The Author(s) 2023.
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页码：1 / 9
页数：8
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