Comparison of three human liver cell lines for in vitro drug-induced liver injury assessment: Huh7, HepaRG, and stem cell-derived hepatocytes

被引：0
作者：
So Yoon Yun
Ju Yeun Kim
Moon Jung Back
Hee Soo Kim
Hae Chan Ha
Ji Min Jang
Dae Kyong Kim
机构：
[1] Chung-Ang University,Department of Environmental and Health Chemistry, College of Pharmacy
来源：
Molecular & Cellular Toxicology | 2019年 / 15卷
关键词：
DILI; Huh7; HepaRG; Stem-cell derived hepatocytes; Hepatotoxicity; Drug metabolic enzymes;
D O I：
暂无
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学科分类号：
摘要：
Backgrounds: Drug-induced liver injury (DILI) is a major causal factor for failure in clinical trials and withdrawal of drugs from pharmaceutical markets. Therefore, a human cell-based in vitro system has been established to overcome the limitations of preclinical trials. However, previous studies focused on the drug metabolism in each cell line or described to be superior in one single cell line for assessing DILI. In this study, we used Huh7, HepaRG, and Hepatosight-S cells to evaluate the liver toxicity and dysfunction driven by DILI-inducing drugs.
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页码：271 / 285
页数：14
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