A 20-year ecological study of the temporal association between influenza and meningococcal disease

被引：28

作者：

Jensen E.S. ^{[1
,5
]}

Lundbye-Christensen S. ^{[2
]}

Samuelsson S. ^{[3
]}

Sørensen H.T. ^{[1
]}

Schønheyder H.C. ^{[4
]}

机构：

[1] Department of Clinical Epidemiology, Aarhus University Hospital, Århus and Aalborg Hospital, Aalborg

[2] Institute of Mathematical Sciences, Aalborg University, Aalborg Ø

[3] Department of Epidemiology, Statens Serum Institut, Copenhagen

[4] Department of Clinical Microbiology, Aalborg Hospital, Aalborg

[5] DK-9520 Skørping

来源：

European Journal of Epidemiology | 2004年 / 19卷 / 2期

关键词：

Age factors; Ecological study; Influenza; Meningococcal disease; Poisson regression; Temporal association;

D O I：

10.1023/B:EJEP.0000017659.80903.5f

中图分类号：

学科分类号：

摘要：

Both influenza and meningococcal disease (MD) show seasonal variation with peak incidence rates during the winter. We examined whether fluctuations in occurrence of influenza were associated with changes in the incidence rate of MD, either simultaneously or with a delay of one or 2 weeks, and whether age had an impact on these associations. This ecological study was based on weekly surveillance data on influenza and a complete registration of MD cases (n = 413) in North Jutland County, Denmark, during 1980-1999. A total of 379 MD cases occurred during weeks with influenza registration. The analysis was done using a Poisson regression model taking into account the seasonal variation and trend over time in incidence rate of MD, and stratified by age: <1 year (n = 38), 1-14 years (n = 189), and ≥ 14 years (n = 152). An increase of 100 registered cases of influenza per 100,000 inhabitants was associated with a 7% (95% CI: -1 to 15%) increase in the number of MD cases during the same week. The association was most marked for < 1 year-olds, corresponding to a 29% (95% CI: 6-58%) increase in the number of MD cases per 100 cases of influenza per 100,000 inhabitants. Our findings support the theory that the influenza detection rate is associated with the number of MD cases in the population during the same week.

引用

页码：181 / 187

页数：6

共 20 条

[1] Connolly M., Noah N.D., Is group C meningococcal disease increasing in Europe? A report of surveillance of meningococcal infection in Europe 1993-1996, Epidemiol Infect, 122, pp. 41-49, (1999)
[2] Stuart J.M., Robinson P.M., Cartwright K., Noah N.D., Antibiotic prescribing during an outbreak of meningococcal disease, Epidemiol Infect, 117, pp. 103-105, (1996)
[3] Cartwright K., Jones D.M., Smith A.J., Stuart J.M., Kaczmarski E.B., Palmer S.R., Influenza A and meningococcal disease, Lancet, 338, pp. 554-557, (1991)
[4] Hubert B., Watier L., Garnerin P., Richardson S., Meningococcal disease and influenza-like syndrome: A new approach to an old question, J Infect Dis, 166, pp. 542-545, (1992)
[5] Cartwright K., Meningococcal carriage and disease, Meningococcal Disease, pp. 115-146, (1995)
[6] Sim R.J., Harrison M.M., Moxon E.R., Tang C.M., Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing, Lancet, 356, pp. 1653-1654, (2000)
[7] Hope-Simpson R.E., The role of season in the epidemiology of influenza, J Hyg Camb, 86, pp. 35-47, (1981)
[8] Wachmann C.H., Uses of Epidemic and Statistical Models in the Surveillance of Infectious Diseases, (1997)
[9] Monto A.S., Sullivan K.M., Acute respiratory illness in the community. Frequency of illness and the agents involved, Epidemiol Infect, 110, pp. 145-160, (1993)
[10] Fleming D.M., Zambon M., Bartelds A.I., Population estimates of persons presenting to general practitioners with influenza-like illness, 1987-1996: A study of the demography of influenza-like illness in sentinel practice networks in England and Wales, and in The Netherlands, Epidemiol Infect, 124, pp. 245-253, (2000)

← 1 2 →