Reproducibility of the 75 g oral glucose tolerance test for the diagnosis of gestational diabetes mellitus in a sub-Saharan African population

被引：15
作者：
Munang Y.N. [1 ]
Noubiap J.J. [2 ]
Danwang C. [3 ]
Sama J.D. [4 ]
Azabji-Kenfack M. [5 ]
Mbanya J.C. [1 ,6 ,7 ]
Sobngwi E. [1 ,6 ,7 ,8 ]
机构：
[1] Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé i, Yaoundé
[2] Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town
[3] Department of Surgery and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé i, Yaoundé
[4] Department of Obstetrics and Gynecology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé i, Yaoundé
[5] Department of Physiology, Faculty of Medicine and Biomedical Sciences, University of Yaoundé i, Yaoundé
[6] Laboratory for Molecular Medicine and Metabolism, Biotechnology Center, University of Yaoundé i, Yaoundé
[7] National Obesity Center, Yaoundé Central Hospital, Yaoundé
[8] National Obesity Center, Yaoundé Central Hospital, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé
来源：
BMC Research Notes | / 10卷 / 1期
关键词：
Africa; Cameroon; Gestational diabetes; Oral glucose tolerance test; Reproducibility;
D O I：
10.1186/s13104-017-2944-7
中图分类号：
学科分类号：
摘要：
Objective: To evaluate the reproducibility of the 75 g oral glucose tolerance test and factors associated with non-reproducible results in Cameroonian pregnant women. Results: Twenty-seven of the 84 participants (32.1%) who did the first oral glucose tolerance test were diagnosed with gestational diabetes mellitus. There was no difference between the means of the glycaemic responses at T0 (p = 0.64), T30 (p = 0.08), T60 (p = 0.86), T90 (p = 0.51), and T120 (p = 0.34) between the two oral glucose tolerance test. Age (p = 0.001) and BMI (p = 0.001) were significantly associated with non-reproducible results. The reproducibility of the oral glucose tolerance test in this study was 74.2%, and the kappa statistic's 0.46. In conclusion, the results of the oral glucose tolerance test were reproducible in only 74.2% of pregnant women in this study. This highlights that a single oral glucose tolerance test for the diagnosis of gestational diabetes mellitus should be interpreted with caution. © 2017 The Author(s).
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