Mitochondrial dysfunction is a key pathological driver of early stage Parkinson’s

被引:0
作者
Christina E. Toomey
Wendy E. Heywood
James R. Evans
Joanne Lachica
Sarah N. Pressey
Sandrine C. Foti
Mesfer Al Shahrani
Karishma D’Sa
Iain P. Hargreaves
Simon Heales
Michael Orford
Claire Troakes
Johannes Attems
Ellen Gelpi
Miklos Palkovits
Tammaryn Lashley
Steve M. Gentleman
Tamas Revesz
Kevin Mills
Sonia Gandhi
机构
[1] UCL Queen Square Institute of Neurology,Queen Square Brain Bank for Neurological Disorders
[2] UCL Queen Square Institute of Neurology,Department of Clinical and Movement Neurosciences
[3] The Francis Crick Institute,Translational Mass Spectrometry Research Group, Genetic & Genomic Medicine
[4] Institute of Child Health,Department of Neurodegenerative Disease
[5] UCL,National Hospital for Neurology and Neurosurgery & Neurometabolic Unit
[6] UCL Queen Square Institute of Neurology,College of Applied Medical Sciences
[7] UCL Great Ormond Street Institute of Child Health,Newcastle Brain Tissue Resource
[8] King Khalid University,Neurological Tissue Bank
[9] London Neurodegenerative Diseases Brain Bank,Division of Neuropathology and Neurochemistry, Department of Neurology
[10] Institute of Psychiatry,Department of Brain Sciences
[11] Psychology & Neuroscience,undefined
[12] King’s College London,undefined
[13] Institute of Neuroscience and Newcastle University Institute for Ageing,undefined
[14] University of Barcelona,undefined
[15] Medical University of Vienna,undefined
[16] Human Brain Tissue Bank,undefined
[17] Budapest,undefined
[18] Semmelweis University,undefined
[19] Imperial College London,undefined
来源
Acta Neuropathologica Communications | / 10卷
关键词
Parkinson’s; Mitochondria; Brain; Progression; Neurodegeneration; Proteomics;
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[1]  
Hou Y(2019)Ageing as a risk factor for neurodegenerative disease Nat Rev Neurol 15 565-581
[2]  
Dan X(2014)α-Synucleinopathy phenotypes Parkinsonism Relat Disord 20 S62-S67
[3]  
Babbar M(2019)Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes Nat Neurosci 22 1099-1109
[4]  
McCann H(2003)Staging of brain pathology related to sporadic Parkinson’s disease Neurobiol Aging 24 197-211
[5]  
Stevens CH(2013)Caudo-rostral brain spreading of α-synuclein through vagal connections EMBO Mol Med 5 1119-1127
[6]  
Cartwright H(2003)Alpha-synuclein pathology in Parkinson’s and Alzheimer's disease brain: incidence and topographic distribution–a pilot study Acta Neuropathol 106 191-201
[7]  
Halliday GM(2015)Familial parkinson disease-associated mutations alter the site-specific microenvironment and dynamics of α-synuclein J Biol Chem 290 7804-7822
[8]  
Shahmoradian SH(1999)alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson’s disease J Biol Chem 274 19509-19512
[9]  
Lewis AJ(1998)Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease Nat Med 4 1318-1320
[10]  
Genoud C(2008)Controlling the mass action of alpha-synuclein in Parkinson’s disease J Neurochem 107 303-316