Colloidal stability of silver nanoparticles in biologically relevant conditions

被引：0
作者：
Robert I. MacCuspie
机构：
[1] National Institute of Standards and Technology,
[2] Ceramics Division,undefined
来源：
Journal of Nanoparticle Research | 2011年 / 13卷
关键词：
Silver nanoparticles; BSA-coated nanoparticles; Nanomaterial dispersion protocol; Nanomaterial characterization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Understanding the colloidal stability of nanoparticles (NPs) plays a key role in phenomenological interpretation of toxicological experiments, particularly if single NPs or their aggregates or agglomerates determine the dominant experimental result. This report examines a variety of instrumental techniques for surveying the colloidal stability of aqueous suspensions of silver nanoparticles (AgNPs), including atomic force microscopy, dynamic light scattering, and colorimetry. It was found that colorimetry can adequately determine the concentration of single AgNPs that remained in solution if morphological information about agglomerates is not required. The colloidal stability of AgNPs with various surface capping agents and in various solvents ranging from cell culture media to different electrolytes of several concentrations, and in different pH conditions was determined. It was found that biocompatible bulky capping agents, such as bovine serum albumin or starch, that provided steric colloidal stabilization, as opposed to purely electrostatic stabilization such as with citrate AgNPs, provided better retention of single AgNPs in solution over a variety of conditions for up to 64 h of observation.
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页码：2893 / 2908
页数：15
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