Formation of 3,4,5,6-tetrahydroquinazolin-2(1H)-one derivatives in reaction of 4-aryl-6-methyl-3,4-dihydro-pyrimidin-2(1H)-ones with chalcones

被引：0
作者：
M. A. Kolosov
O. G. Kulyk
O. I. Starchenko
V. D. Orlov
机构：
[1] V. N. Karazin Kharkiv National University,
来源：
Chemistry of Heterocyclic Compounds | 2013年 / 49卷
关键词：
1,3-C,C-bis-nucleophiles; 3,4-dihydropyrimidin-2(1; )-ones; 3,4,5,6-tetrahydroquinazolin-2(1; )-ones; Biginelli compounds; deacylation;
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学科分类号：
摘要：
A procedure for the preparation of 6-methyl-3,4-dihydropyrimidin-2(1H)-ones involving deacylation of 5-acetyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones in MeOH–KOH medium is developed. We have shown that the obtained compounds readily undergo reaction with chalcones in MeOH–MeONa with the formation of derivatives of 4,5,7-triaryl-3,4,5,6-tetrahydroquinazolin-2(1H)-one.
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页码：1166 / 1171
页数：5
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