Current understanding of extrachromosomal circular DNA in cancer pathogenesis and therapeutic resistance

被引：0
作者：
Yuanliang Yan
Guijie Guo
Jinzhou Huang
Ming Gao
Qian Zhu
Shuangshuang Zeng
Zhicheng Gong
Zhijie Xu
机构：
[1] Central South University,Department of Pharmacy, Xiangya Hospital
[2] Mayo Clinic,Department of Oncology
[3] Central South University,Department of Pathology, Xiangya Hospital
[4] Central South University,National Clinical Research Center for Geriatric Disorders, Xiangya Hospital
来源：
Journal of Hematology & Oncology | / 13卷
关键词：
Extrachromosomal circular DNA; Oncogene amplification; Therapeutic resistance; Cancer pathogenesis; Biomarkers; Clinical utility;
D O I：
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学科分类号：
摘要：
Extrachromosomal circular DNA was recently found to be particularly abundant in multiple human cancer cells, although its frequency varies among different tumor types. Elevated levels of extrachromosomal circular DNA have been considered an effective biomarker of cancer pathogenesis. Multiple reports have demonstrated that the amplification of oncogenes and therapeutic resistance genes located on extrachromosomal DNA is a frequent event that drives intratumoral genetic heterogeneity and provides a potential evolutionary advantage. This review highlights the current understanding of the extrachromosomal circular DNA present in the tissues and circulation of patients with advanced cancers and provides a detailed discussion of their substantial roles in tumor regulation. Confirming the presence of cancer-related extrachromosomal circular DNA would provide a putative testing strategy for the precision diagnosis and treatment of human malignancies in clinical practice.
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