Wnt Signaling in Normal and Malignant Stem Cells

被引：27
作者：
Bhavanasi D. [1 ]
Klein P.S. [1 ,2 ]
机构：
[1] Department of Medicine (Hematology-Oncology), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19104, PA
[2] Cell and Molecular Biology Graduate Group, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
来源：
Current Stem Cell Reports | 2016年 / 2卷 / 4期
基金：
美国国家卫生研究院;
关键词：
Adenomatous polyposis coli (APC); Canonical Wnt signaling; Colorectal cancer; GSK-3; Hematopoietic stem cells; Mechanistic target of rapamycin (mTOR);
D O I：
10.1007/s40778-016-0068-y
中图分类号：
学科分类号：
摘要：
Wnt signaling plays important roles in stem cell self-renewal and differentiation in adults as well as in embryonic development. Mutations that activate canonical Wnt/β-catenin signaling also initiate and maintain several cancer states, including colorectal cancer and leukemia, and hence Wnt inhibitors are currently being explored as therapeutic options. In this review, we summarize previous studies and update recent findings on canonical Wnt signaling and its components, as well as their roles in somatic stem cell homeostasis and maintenance of cancer-initiating cells. © 2016, Springer International Publishing AG.
引用
收藏
页码：379 / 387
页数：8
相关论文
共 119 条
[31]  
Mao B., Et al., Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling, Nature, 417, 6889, pp. 664-667, (2002)
[32]  
Hsieh J.C., Et al., A new secreted protein that binds to Wnt proteins and inhibits their activities, Nature, 398, 6726, pp. 431-436, (1999)
[33]  
Lin K., Et al., The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling, Proc Natl Acad Sci U S A, 94, 21, pp. 11196-11200, (1997)
[34]  
Wharton K.A., Vertebrate proteins related to Drosophila Naked cuticle bind Dishevelled and antagonize Wnt signaling, Dev Biol, 234, 1, pp. 93-106, (2001)
[35]  
Rocheleau C.E., Et al., Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos, Cell, 90, 4, pp. 707-716, (1997)
[36]  
Inoki K., Zhu T., Guan K.L., TSC2 mediates cellular energy response to control cell growth and survival, Cell, 115, 5, pp. 577-590, (2003)
[37]  
Acebron S.P., Et al., Mitotic wnt signaling promotes protein stabilization and regulates cell size, Mol Cell, 54, 4, pp. 663-674, (2014)
[38]  
Cook D., Et al., Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C, EMBO J, 15, 17, pp. 4526-4536, (1996)
[39]  
Ruel L., Et al., Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila, EMBO J, 12, 4, pp. 1657-1669, (1993)
[40]  
Ruel L., Et al., Regulation of the protein kinase activity of shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos, J Biol Chem, 274, 31, pp. 21790-21796, (1999)
12345678910