Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: A randomized, double-blind, crossover pilot study

被引：11

作者：

Franziska R. Studer

Klaus W. Grätz

Till S. Mutzbauer

机构：

[1] Department of Craniomaxillofacial and Oral Surgery, University Hospital Zurich, 8091 Zurich

[2] Maxillofacial Surgery and Dental Anesthesiology, CH-8001 Zurich

来源：

Oral and Maxillofacial Surgery | 2012年 / 16卷 / 4期

关键词：

Anxiolysis; Clonidine; Midazolam; Pilot study; Randomized trial; Third molar surgery; Wisdom tooth extraction;

D O I：

10.1007/s10006-012-0319-8

中图分类号：

学科分类号：

摘要：

Purpose: Anxiolytic and possible side effects of clonidine 150 μg compared to midazolam 7. 5 mg for premedication in surgical wisdom tooth extraction were evaluated. Methods: In a prospective, randomized, double-blind crossover trial, ten patients undergoing bilateral wisdom tooth surgery received clonidine or midazolam orally 1 h before the treatment. Patients receiving midazolam for the first surgery received clonidine at the second surgery and vice versa. The anxiolytic efficacy was evaluated with a visual analogue scale (VAS) upon admission and 30, 50 and 60 min after administration of the medication. Patient satisfaction was recorded on a VAS after surgery and 7 days postoperatively. Results: As soon as 30 min after administration of midazolam (p < 0. 03) and clonidine (p < 0. 02), an anxiolytic effect was recorded. Both medications did not differ in patient satisfaction. Conclusion: Oral administration of clonidine 150 μg and midazolam 7. 5 mg were rated as medications with equal anxiolytic effects before wisdom tooth surgery under local anesthesia. © 2012 Springer-Verlag.

引用

页码：341 / 347

页数：6

共 16 条

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