Comparison of clonidine and midazolam as anxiolytic premedication before wisdom tooth surgery: A randomized, double-blind, crossover pilot study

被引：11

作者：

Franziska R. Studer

Klaus W. Grätz

Till S. Mutzbauer

机构：

[1] Department of Craniomaxillofacial and Oral Surgery, University Hospital Zurich, 8091 Zurich

[2] Maxillofacial Surgery and Dental Anesthesiology, CH-8001 Zurich

来源：

Oral and Maxillofacial Surgery | 2012年 / 16卷 / 4期

关键词：

Anxiolysis; Clonidine; Midazolam; Pilot study; Randomized trial; Third molar surgery; Wisdom tooth extraction;

D O I：

10.1007/s10006-012-0319-8

中图分类号：

学科分类号：

摘要：

Purpose: Anxiolytic and possible side effects of clonidine 150 μg compared to midazolam 7. 5 mg for premedication in surgical wisdom tooth extraction were evaluated. Methods: In a prospective, randomized, double-blind crossover trial, ten patients undergoing bilateral wisdom tooth surgery received clonidine or midazolam orally 1 h before the treatment. Patients receiving midazolam for the first surgery received clonidine at the second surgery and vice versa. The anxiolytic efficacy was evaluated with a visual analogue scale (VAS) upon admission and 30, 50 and 60 min after administration of the medication. Patient satisfaction was recorded on a VAS after surgery and 7 days postoperatively. Results: As soon as 30 min after administration of midazolam (p < 0. 03) and clonidine (p < 0. 02), an anxiolytic effect was recorded. Both medications did not differ in patient satisfaction. Conclusion: Oral administration of clonidine 150 μg and midazolam 7. 5 mg were rated as medications with equal anxiolytic effects before wisdom tooth surgery under local anesthesia. © 2012 Springer-Verlag.

引用

页码：341 / 347

页数：6

共 16 条

[1]

Donaldson M., Gizzarelli G., Chanpong B., Oral sedation. A primer on anxiolysis for the adult patient, Anesth Prog, 54, 3, pp. 118-129, (2007)

[2]

Gross J.B., Bailey P.L., Connis R.T., Cote C.J., Davis F.G., Epstein B.S., Gilbertson L., Nickinovich D.G., Zerwas J.M., Zuccaro G., Practice guidelines for sedation and analgesia by non-anesthesiologists: an update report by the American Society of Anesthesiologists task force on sedation and analgesia by non-anesthesiologists, Anesthesiology, 96, pp. 1004-10017, (2002)

[3]

Beer G.M., Spicher I., Seifert B., Emanuel B., Kompatscher P., Meyer V.E., Oral premedication for operations on the face under local anesthesia: a placebo-controlled double-blind trial, Plast Reconstr Surg, 108, pp. 637-643, (2001)

[4]

Murai T., Effects of clonidine on intravenous sedation with midazolam, Anesth Prog, 42, pp. 135-138, (1995)

[5]

Fanini D., Poglio M., Marci M.C., Iovinelli G., Antenucci F., La premedicazione orale con clonidina come alternative nella pratica odontoiatrica, Minerva Stomatol, 47, pp. 453-464, (1998)

[6]

Eberhart L.H., Novatchkov N., Schricker T., Georgieff M., Baur C.P., Clonidin im Vergleich zu Midazolam zur intravenösen Prämedikation vor ambulanten Eingriffen, Anasthesiol Intensivmed Notfallmed Schmerzther, 35, pp. 388-393, (2000)

[7]

Frank T., Thieme V., Radow L., Prämedikation im Rahmen einer TIVA bei kieferchirurgischen Operationen-Vergleich der perioperativen Verläufe nach Clonidin versus Midazolam, Anästhesiol Intensivmed Notfallmed Schmerzther, 35, pp. 428-434, (2000)

[8]

Altman D.G., Practical Statistics for Medical Research, (1991)

[9]

Berendes E., Scherer R., Rotthove K., Prien T., Anxiolyse, Sedierung und Stressreduktion nach oraler Prämedikation mit Midazolam bei Erwachsenen. Ein Vergleich mit Dikaliumclorazepat bzw, Plazebo. Anaesthesist, 45, pp. 506-511, (1996)

[10]

Zalunardo M.P., Ivleva-Sauerborn A., Seifert B., Spahn D.R., Quality of premedication and patient satisfaction after premedication with midazolam, clonidine or placebo: randomized double-blind study with age-adjusted dosage, Anaesthesist, 59, 5, pp. 410-418, (2010)

← 1 2 →