Innate immune response to La Crosse virus infection

被引：0
作者：
Katherine G. Taylor
Karin E. Peterson
机构：
[1] National Institutes of Health,Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases
来源：
Journal of NeuroVirology | 2014年 / 20卷
关键词：
La Crosse; Encephalitis; Innate; SARM1; Interferon;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Viral encephalitis represents a significant, and costly, public health threat particularly for high-risk pediatric populations. An emerging mosquito-borne pathogen endemic to the United States, La Crosse virus (LACV) is one of the most common causes of viral encephalitis in children in the United States. However, no licensed therapeutics or vaccines currently exist for treatment. Hampering development efforts, the host response to LACV and its role in disease pathogenesis has only recently been examined. In this review, we discuss the current understanding of innate immune response in the context of viral pathogenesis and host susceptibility to LACV. In addition, we address the need for a clearer understanding of the early host–virus interactions in LACV infections as it relates to viral pathogenesis in the central nervous system.
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页码：150 / 156
页数：6
相关论文
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