MiR-485-3p/MiR-543/MiR-337-3p is Required for the Oncogenic Potential of the Hsa_circ_0007385-MEMO1 Axis in Colorectal Cancer

被引：1
|
作者：
Ying, Junfeng [1 ,2 ]
Liu, Guanglan [3 ]
Zhu, Xinguo [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Gen Surg, 188 Shizi St, Suzhou 215006, Jiangsu, Peoples R China
[2] Yangzhou Univ, Affiliated Hosp, Dept Gen Surg, Yangzhou 225000, Jiangsu, Peoples R China
[3] Ganyu Dist Peoples Hosp, Dept Gen Surg, Lianyungang 222100, Jiangsu, Peoples R China
来源：
BIOCHEMICAL GENETICS | 2024年 / 62卷 / 02期
关键词：
Circular RNA; MicroRNA; ceRNA network; Cancer progression; MESSENGER-RNA; METASTASIS; DIAGNOSIS;
D O I：
10.1007/s10528-023-10472-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Circular RNAs (circRNAs) play regulatory roles in the biological processes of multiple tumors, colorectal cancer (CRC) included. Our previous study probed the impact of circ_0007385 on CRC cell malignant behaviors, while the underlying mechanism remains obscure. In this work, the potential mechanism of hsa_circ_0007385 in CRC was probed. Functional experiments were implemented for probing the function of hsa_circ_0007385 in CRC. Further analysis revealed the relation between hsa_circ_0007385 and miRNAs. A xenograft mouse model was implemented for probing the influence of hsa_circ_0007385 on CRC growth and metastasis in vivo. Hsa_circ_0007385 was up-regulated in CRC. Hsa_circ_0007385 positively regulated its host gene mediator of cell motility 1 (MEMO1). Hsa_circ_0007385 silencing inhibited CRC progression. Hsa_circ_0007385 and MEMO1 bond to miR-485-3p/miR-543/miR-337-3p, and these three miRNAs were lowly expressed in CRC, and negatively modulated by hsa_circ_0007385. Hsa_circ_0007385 functioned as an oncogene in CRC in a miR-485-3p/miR-543/miR-337-3p- or MEMO1-dependent manner. Hsa_circ_0007385 promoted CRC progression via modulating miR-485-3p/miR-543/miR-337-3p/MEMO1 axis. Thus, circ-MEMO1 might be a promising therapeutic target for CRC.
引用
收藏
页码：1182 / 1199
页数：18
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